2011年12月1日 · In response to UV–DNA damage, DDB1 targets the replication licensing protein (Cdt1) for ubiquitination and mediates its rapid degradation. This mechanism prevents the replication of damaged DNA, contributing to DNA repair and the maintenance of genome integrity.

2019年5月29日 · Here we report cryo-electron microscopy structures of UV-DDB bound to nucleosomes bearing a 6–4 pyrimidine–pyrimidone dimer or a DNA-damage mimic in various positions. We find that UV-DDB binds...

近日，Nature杂志在线发表了由瑞士弗里德里希·米舍尔生物医学研究所（Friedrich Miescher Institute for Biomedical Research）Nicolas H. Thomä团队题为DNA damage detection in nucleosomes involves DNA register shifting 的长文，报道了UV-DDB与在不同位置存在6-4光产物或是类DNA损伤的核小体结合 ...

DNA damage-binding protein or UV-DDB [1] is a protein complex that is responsible for repair of UV-damaged DNA. [2] This complex is composed of two protein subunits, a large subunit DDB1 (p127) and a small subunit DDB2 (p48).

2024年12月24日 · DDB1 (Damage Specific DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A a …

2009年8月6日 · UV-DDB was identified as a heterodimer containing DDB1 and DDB2 proteins [12]. DDB2 seems to be a specific component of UV-DDB and responsible for its damaged DNA-binding activity, whereas DDB1 forms various complexes with different partners and thus has a much broader range of functions ( [13] ; see also below).

A UV-DDB1-2 heterodimer increased both OGG1 and APE1 strand cleavage and DNA polymerase beta-gap filling activity. It forms transient complexes with OGG1 or APE1, facilitating their dissociation from DNA. It moves to sites of 8-oxoG repair in cells. Its depletion sensitizes cells to oxidative DNA damage.

2019年7月22日 · UV-DDB increased both OGG1 and APE1 strand cleavage and stimulated subsequent DNA polymerase β-gap filling activity by 30-fold. Single-molecule real-time imaging revealed that UV-DDB forms...

Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the nucleotide excision repair pathway. DDB1 and DDB2 form a complex that promotes the global genome repair (GG-NER) …