
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
2011年12月1日 · In response to UV–DNA damage, DDB1 targets the replication licensing protein (Cdt1) for ubiquitination and mediates its rapid degradation. This mechanism prevents the …
DNA damage detection in nucleosomes involves DNA register …
2019年5月29日 · Here we report cryo-electron microscopy structures of UV-DDB bound to nucleosomes bearing a 6–4 pyrimidine–pyrimidone dimer or a DNA-damage mimic in various …
Nature长文 | 存在“访问限制”的核小体中DNA损伤是如何被识别 …
近日,Nature杂志在线发表了由瑞士弗里德里希·米舍尔生物医学研究所(Friedrich Miescher Institute for Biomedical Research)Nicolas H. Thomä团队题为DNA damage detection in …
DNA damage-binding protein - Wikipedia
DNA damage-binding protein or UV-DDB [1] is a protein complex that is responsible for repair of UV-damaged DNA. [2] This complex is composed of two protein subunits, a large subunit …
DDB1 Gene - GeneCards | DDB1 Protein | DDB1 Antibody
2024年12月24日 · DDB1 (Damage Specific DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma …
Expanding molecular roles of UV-DDB: Shining light on genome ... - PubMed
UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are …
UV-DDB: A molecular machine linking DNA repair with …
2009年8月6日 · UV-DDB was identified as a heterodimer containing DDB1 and DDB2 proteins [12]. DDB2 seems to be a specific component of UV-DDB and responsible for its damaged …
DDB1 damage specific DNA binding protein 1 [ (human)]
A UV-DDB1-2 heterodimer increased both OGG1 and APE1 strand cleavage and DNA polymerase beta-gap filling activity. It forms transient complexes with OGG1 or APE1, …
Damage sensor role of UV-DDB during base excision repair
2019年7月22日 · UV-DDB increased both OGG1 and APE1 strand cleavage and stimulated subsequent DNA polymerase β-gap filling activity by 30-fold. Single-molecule real-time …
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the …