2011年12月1日 · In response to UV–DNA damage, DDB1 targets the replication licensing protein (Cdt1) for ubiquitination and mediates its rapid degradation. This mechanism prevents the …

2019年5月29日 · Here we report cryo-electron microscopy structures of UV-DDB bound to nucleosomes bearing a 6–4 pyrimidine–pyrimidone dimer or a DNA-damage mimic in various …

近日，Nature杂志在线发表了由瑞士弗里德里希·米舍尔生物医学研究所（Friedrich Miescher Institute for Biomedical Research）Nicolas H. Thomä团队题为DNA damage detection in …

DNA damage-binding protein or UV-DDB [1] is a protein complex that is responsible for repair of UV-damaged DNA. [2] This complex is composed of two protein subunits, a large subunit …

2024年12月24日 · DDB1 (Damage Specific DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma …

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are …

2009年8月6日 · UV-DDB was identified as a heterodimer containing DDB1 and DDB2 proteins [12]. DDB2 seems to be a specific component of UV-DDB and responsible for its damaged …

A UV-DDB1-2 heterodimer increased both OGG1 and APE1 strand cleavage and DNA polymerase beta-gap filling activity. It forms transient complexes with OGG1 or APE1, …

2019年7月22日 · UV-DDB increased both OGG1 and APE1 strand cleavage and stimulated subsequent DNA polymerase β-gap filling activity by 30-fold. Single-molecule real-time …

Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the …