Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene. [5] [6] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

Dec 24, 2024 · DDX41 (DEAD-Box Helicase 41) is a Protein Coding gene. Diseases associated with DDX41 include Myeloproliferative/Lymphoproliferative Neoplasms, Familial and Ddx41-Related Hematologic Malignancy Predisposition Syndrome .

Aug 18, 2022 · These studies strengthen claims that acute myeloid leukemia (AML) with DDX41 MutGL represents a unique clinicopathological entity. It is typically characterized by late‐onset disease, normal karyotype, male sex skewing (2.7:1), and favorable outcome.

Dec 4, 2023 · Deleterious germ line variants in DDX41 are a common cause of genetic predisposition to hematologic malignancies, particularly myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML).

Feb 2, 2023 · Here we reveal the spectrum of common pathogenic DDX41 germ line variants across multiple ethnicities, estimate the age-related risk of MN development ascribed to pathogenic DDX41 germ line variants, and unveil their unique genetic and clinical features, through a large international collaboration accruing 346 DDX41-mutated MN cases.

Nov 25, 2024 · DDX41-Associated Myeloid Malignancies is a hereditary hematologic malignancy syndrome associated with the DDX41 gene. Learn about DDX41's clinical features and management.

DDX41-related hematologic malignancy predisposition syndrome is a rare inherited condition. It makes people more likely to develop certain types of blood cancers when they are adults. These cancers mainly affect a specific type of blood cell called myeloid cells.

Your cancer sample has shown an alteration in a gene called DDX41. This information sheet will help you understand what this means. This gene alteration may partly explain why you have blood cancer. It may be used to help guide your treatment plan. The DDX41 gene alteration may only be present in your cancer cells. It is also possible that it ...

HGNC Approved Gene Symbol: DDX41. Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38) : 5:177,511,577-177,516,961 (from NCBI) The DDX41 gene encodes an RNA helicase. Evidence suggests that it also acts as a tumor suppressor gene …

Jan 5, 2023 · The DEAD-box RNA helicase 41 gene, DDX41, is frequently mutated in hereditary myeloid neoplasms, identified in 2% of entire patients with AML/MDS. The pathogenesis of DDX41 mutation is related to the defect in the gene’s …