DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene. …

Nov 12, 2020 · DEP-domain containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, has essential roles in several processes, including cell growth, metabolism, …

We identify DEPTOR, also called DEPDC6, as an mTOR-interacting protein whose expression is negatively regulated by mTORC1 and mTORC2. Loss of DEPTOR activates S6K1, Akt, and …

Mar 28, 2025 · DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a Protein Coding gene. Diseases associated with DEPTOR include Metaphyseal Chondrodysplasia, Jansen …

Feb 8, 2025 · DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Mechanistically, DEPTOR inhibited both mTOR Complex 1 …

Jan 13, 2017 · Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR …

Deptor is a protein that interacts with mTOR and that belongs to the mTORC1 and mTORC2 complexes. Deptor is capable of inhibiting the kinase activity of mTOR.

May 27, 2021 · Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an …

Jul 1, 2018 · DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a kinase at the center of two important protein …

Apr 1, 2025 · DEPTOR S275A suppresses lymphomagenesis triggered by Pten heterozygous loss in vivo. We and the others previously found that DEPTOR is a substrate of SCF β-TrCP …