Deubiquitinating enzyme - Wikipedia
Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, or ubiquitin isopeptidases, are a large group of proteases [1] that cleave ubiquitin from proteins. [2] .
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and …
To regulate this process, deubiquitinating enzymes (DUBs) counter the signal induced by ubiquitin conjugases and ligases by removing ubiquitin from these substrates. Many DUBs selectively regulate physiological pathways employing conserved mechanisms of ubiquitin bond cleavage.
Mechanism and function of deubiquitinating enzymes
2004年11月29日 · Attachment of ubiquitin to proteins is a crucial step in many cellular regulatory mechanisms and contributes to numerous biological processes, including embryonic development, the cell cycle, growth control, and prevention of neurodegeneration.
Deubiquitinases: From mechanisms to their inhibition by small molecules
2022年1月6日 · Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of DUB function.
Deubiquitinases: From mechanisms to their inhibition by small molecules
2022年1月6日 · Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of …
Deubiquitinating enzymes and the proteasome regulate ... - Nature
2022年5月18日 · We uncover large dynamic ubiquitin signalling networks with substrates and sites preferentially regulated by DUBs or by the proteasome, highlighting the role of DUBs in degradation-independent...
Mechanisms of Deubiquitinase Specificity and Regulation
2017年6月20日 · Deubiquitinases (DUBs) reverse ubiquitin signals with equally high sophistication. In this review, we conceptualize the many layers of specificity that DUBs encompass to control the ubiquitin code and discuss examples in which DUB specificity has been understood at the molecular level.
The Role of Deubiquitinating Enzymes in the Various Forms of …
2020年6月12日 · Deubiquitinating enzymes (DUBs) have an essential role in several cell biological processes via removing the various ubiquitin patterns as posttranslational modification forms from the target proteins. These enzymes also contribute to the normal cytoplasmic ubiquitin pool during the recycling of this molecule.
Deubiquitination complex platform: A plausible mechanism for
Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome degradation and are critical for regulating protein expression levels <i>in vivo</i>. Therefore, dissecting the underlying mechanism of DUB recognition is needed to advance the dev …
Deubiquitinases in cancer - Nature Reviews Cancer
2023年11月7日 · Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in cellular signalling are central to cancer initiation, progression and, eventually, metastasis. The...