To regulate this process, deubiquitinating enzymes (DUBs) counter the signal induced by ubiquitin conjugases and ligases by removing ubiquitin from these substrates. Many DUBs selectively regulate physiological pathways employing conserved mechanisms of ubiquitin bond cleavage.

Jan 14, 2021 · Deubiquitination is performed by deubiquitinases (DUBs) that remove ubiquitin modifications from substrates. B Schematic representation and examples of some of the ubiquitin modifications...

Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation.

Jan 6, 2022 · Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of DUB function.

Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction.

Nov 7, 2023 · Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in cellular signalling are central to cancer initiation, progression and, eventually, metastasis....

Jul 25, 2024 · We clarify the fundamental mechanisms and functions of ubiquitination and deubiquitination in tumor suppression, metabolic reprogramming, immune evasion, phenotypic plasticity, polymorphic microbiomes, and other essential cellular functions, focusing on …

Nov 29, 2004 · Polyubiquitin attachment targets many intracellular proteins for degradation by the proteasome, and (mono)ubiquitination is often required for down-regulating plasma membrane proteins by targeting them to the vacuole (lysosome). Ubiquitin–protein conjugates are highly dynamic structures.

Jan 22, 2021 · Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting...

Deubiquitination by DUBs serves two purposes: (1) reversing ubiquitination of a protein or (2) disassembling the polyubiquitin chains before the ubiquitinated proteins are channeled to the 26S proteasome. Disassembly of polyubiquitin chains at the proteasome step is probably a rate-limiting step for degradation.