Tetrahydrofolic acid (THF) is an important biochemical intermediate that plays a crucial role in reactions involving the addition of a single carbon atom, such as the synthesis of the purine …

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of …

2020年9月6日 · Tetrahydrofolate (THF) or tetrahydrofolic acid is a derivative of vitamin B9 (folic acid or pteroyl-L-glutamic acid). This water-soluble vitamin is a coenzyme for metabolic …

1. 叶酸被二氢叶酸还原酶 (DHFR) 还原为二氢叶酸 (DHF)，然后再还原为四氢叶酸 (tetrahydrofolate, THF)。 2. THF 可用于嘌呤合成，通过使用甲酸盐作为一碳供体转化为 10-甲 …

DHF, THF, and 10-formyl-THF are efficient substrates for FPGS, whereas 5-methyl-THF, 5-formyl-THF, and folic acid are poor substrates (Cichowicz and Shane, 1987). Because 5 …

Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA …

One carbon metabolism or the folate cycle utilizes four enzymes, dihydrofolate reductase (DHFR), serine hydroxymethyltransferase-1 (SHMT1), and methylenetetrahydrofolate Dehydrogenase …

2019年4月5日 · DHP is further converted to dihydrofolate (DHF) in the reaction mediated by dihydrofolate synthetase (DHFS), which attaches the first glutamate residue to the carboxyl …

二氢叶酸还原酶，或称DHFR，是一种将二氢叶酸还原为四氢叶酸的酶，使用NADPH作为电子供体，可以转化为1-碳转移化学中使用的四氢叶酸辅因子。 在人类中，DHFR酶由 DHFR 吉恩。 …

2014年1月1日 · Folate species DHF and THF do not play a direct role in metabolism, but receive one-carbon moieties and transfer them toward either methylation or DNA-synthesis pathways. …