Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone -mediated oxidation of dihydroorotate to orotate, in de …

二氢乳清酸脱氢酶（DHODH，Dihydroorotate Dehydrogenase）是一种含铁的黄素依赖的线粒体酶，是核酸催化中嘧啶合成的关键酶，催化嘧啶从头生物合成途径中的第四步反应。 作为一种与电子传递链相关的酶，DHODH 将线粒体能量、细胞增殖、ROS 产生和某些细胞类型的细胞凋亡联系起来。 DHODH 耗竭还导致 ROS 产生增加、膜电位降低和细胞生长迟缓。 阻断DHODH合成通路，可有效抑制活化免疫细胞的增殖和细胞因子的分泌，从而抑制疾病导致的细胞因子风暴。 …

2024年12月24日 · DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Developmental Dysplasia Of The Hip 1 and Developmental Dysplasia Of The Hip 2. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.

We demonstrated that D-xylose supplementation could enhance the proliferation of CD8 + T cells and the expression of cytotoxic markers against cocultured DHDH-wild type (WT) cells.

Wu et al. performed bioinfor-matics analysis using FUSCC TNBC multi-omics data and identified a key metabolic enzyme, dihydrodiol de-hydrogenase (DHDH), which is correlated with low immune infiltration. They found that D-xylose supplementation promoted CD8+ T cell infiltration and the expression of cytotoxic markers and.

2024年11月8日 · Through bioinformatics analysis, we found that a metabolic enzyme, dihydrodiol dehydrogenase (DHDH), which is highly expressed in nonimmune-inflamed TNBC, could deplete D-xylose in the tumor microenvironment to inactivate the immune response and cytotoxic T …

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2025年2月8日 · Survival was significantly better in gastric cancer patients with low DDH expression. Title: Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients. Observational study …

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DHDH的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为这个基因编码属于该家族二氢二醇脱氢酶，存在于多种形式在哺乳动物组织，并参与异生素和糖的代谢的酶。 这些酶催化芳香烃transdihydrodiols的NADP1联氧化相应儿茶酚。 这种酶是二聚体二氢二醇脱氢酶，并且它在其底物特异性高在氧化方向芳烃的反式dihydrodiols单体二氢二醇脱氢酶不同。 [由RefSeq的，2008年7月提供]