2002年5月1日 · Molecular interactions between two Ca 2+ ion channel proteins, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR), underlie the essential process of excitation–contraction (EC) coupling in skeletal and cardiac muscle.

Dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) interact during EC coupling within calcium release units, CRUs. The location of the two channels and their positioning are related to their role in EC coupling. alphals DHPR and RyR1 of …

2005年2月16日 · 二氢吡啶受体（DHPRs）和ryanodine受体（RyRs）在钙释放单元CRU中的EC偶联过程中相互作用。 这两个通道的位置及其位置与其在EC耦合中的作用有关。 骨骼肌的alphals DHPR和RyR1形成互锁的阵列。 四个DHPR（形成一个四联体）的组位于备用RyR1上。 这种关联为两个通道之间的相互信令提供了结构框架。 RyR3与RyR1结合存在于某些骨骼肌中，比例最高为1：1。 RyR3既不会诱导DHPR形成四链体，也不会维持EC偶联。 RyR3位于RyR1 …

2002年3月1日 · Ultrastructural studies show that functional differences can be explained by differences in the DHPR/RyR reciprocal association: whereas the two proteins are very close to each other in both muscles, DHPRs form tetrads only in skeletal fibers.

2010年1月1日 · DHPR and RyR Arrangement in Skeletal and Cardiac Muscle Membranes—Basis for Differences in the EC Coupling Mechanism. The principal qualitative difference in the mode of EC coupling between skeletal and cardiac muscle is mirrored in skeletal- and cardiac-specific localization of DHPRs relative to the adjacent RyRs.

2011年10月13日 · Dihydropyridine (DHPR) and ryanodine receptors (RyRs) are central to transduction of transverse (T) tubular membrane depolarisation initiated by surface action potentials into release of sarcoplasmic reticular (SR) Ca 2+ in skeletal muscle excitation–contraction coupling.

Dihydropyridine (DHPR) and ryanodine receptors (RyRs) are central to transduction of transverse (T) tubular membrane depolarisation initiated by surface action potentials into release of sarcoplasmic reticular (SR) Ca2+ in skeletal muscle excitation-contraction coupling.

1997年2月2日 · Here we have examined the ability of the predominant cardiac and brain RyR isoform, RyR-2, to substitute for RyR-1 in interacting with the skeletal DHPR. When RyR-2 is expressed in dyspedic muscle cells, it gives rise to spontaneous intracellular Ca 2+ oscillations and supports Ca 2+ entry-induced Ca 2+ release.

兴奋-收缩偶联(E-C coupling)依赖细胞膜二氢吡啶受体(DHPR)/L型电压门控Ca2+通道和肌浆网兰诺定受体(RyR)/Ca2+释放通道的相互作用.在骨骼肌 细胞中,DHPR与RyR1在结构上机械偶联,不依赖细胞外Ca2+即可激活RyR1;在心肌细胞中,去极化激活DHPR,细胞外Ca2+内流,内流的 Ca2+通过 …

2015年2月10日 · Dihydropyridine receptor (DHPR), an L-type Ca 2+ channel complex, plays an essential role in muscle contraction, secretion, integration of synaptic input in...