2024年12月24日 · DHX58 (DExH-Box Helicase 58) is a Protein Coding gene. Diseases associated with DHX58 include Measles and Rabies. Among its related pathways are Innate Immune System and DDX58/IFIH1-mediated induction of interferon-alpha/beta. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity.

Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene.

2025年2月8日 · DHX58 expression positively correlate with osteogenic process. DHX58 overexpression enhances osteogenesis via the Wnt/beta-Catenin pathway. characterize the involvement of PACT in the synergy between LGP2 and MDA5; LGP2 represses specific miRNA activities by interacting with TRBP, resulting in selective regulation of target genes.

Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

2025年2月8日 · Enables several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in negative regulation of type I interferon production and regulation of innate immune response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Feb 2025]

WNV-infected, Dhx58-deficient mice showed increased mortality but similar kinetics of IFNβ production and tissue viral loads compared with WT mice. In the brain they displayed increased neuronal damage, elevated viral load in a late phase of infection, low neuroinflammation and decreased recruitment of CD8 + T cells [ 14 ].

2025年2月8日 · DHX58 expression positively correlate with osteogenic process. DHX58 overexpression enhances osteogenesis via the Wnt/beta-Catenin pathway. These findings provide a unique mechanism for LGP2 negative regulation through TRAF suppression and extend the potential impact of LGP2 negative regulation beyond the IFN antiviral response.

2024年4月15日 · This study provides mechanistic evidence that IFN-α stimulates DHX58 to promote the translation of m 6 A-modified Gpx4 mRNA, suggesting the potential clinical application of IFN-α in the prevention of hepatic ferroptosis during liver I/R injury.

RNA 解旋酶 DDX5 通过调节 DHX58 和 NFκB 转录本上的 N6-甲基腺苷水平来抑制抗病毒先天免疫，从而促进病毒感染。 PLoS Pathogens ( IF 5.5) Pub Date : 2021-04-28, DOI: 10.1371/journal.ppat.1009530

Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Recessive Spondylocarpotarsal Synostosis Syndrome Due to Compound Heterozygosity for Variants in MYH3. A locus for spondylocarpotarsal synostosis syndrome at chromosome 3p14.