2023年2月3日 · We found that pY701-STAT1 levels were comparable in BMDMs from Dhx9 f/f LysM-Cre and Dhx9 f/f mice after IFN-β stimulation (fig. S8). DHX9 has been extensively characterized as a transcriptional regulator and is a bridging factor between the transcriptional coactivator adenosine 3′,5′-monophosphate response element–binding protein (CREB ...

2024年3月18日 · Here, we identified a distinct stress granule (SG), marked by dsRNA helicase DHX9, which compartmentalizes ultraviolet (UV)-induced RNA, but not DNA, damage. Our FANCI technology revealed that DHX9 SGs are enriched in damaged intron RNA, in contrast to classical SGs that are composed of mature mRNA.

2022年2月9日 · We found that T cell–specific deletion of nuclear helicase Dhx9 led to impaired CD8 + T cell survival, effector differentiation, and viral clearance. Mechanistically, Dhx9 acts as the key regulator to ensure LCK- and CD3ε-mediated ZAP70 phosphorylation and ERK activation to protect CD8 + T cells from

2023年8月3日 · DHX9 encodes a BRCA1-interacting nuclear helicase regulating transcription, R-loops, and homologous recombination and exhibits the highest mutational constraint of all DDX / DHX paralogs but remains unassociated with disease traits in OMIM.

2025年2月17日 · In this report, we show that DHX9 knockdown increased RNA/DNA secondary structures and replication stress, resulting in cell-cycle arrest and the onset of apoptosis in cancer cells with MSI-H/dMMR. ATX968 was identified as a potent and selective inhibitor of DHX9 helicase activity.

2020年6月15日 · Consistently, pRPA2 S4/S8 signal induced by CPT treatment was disturbed by depleting endogenous DHX9 (data not shown), which tended to be rescued by transient over-expression of siRNA-resistant...

2023年2月9日 · dhx9是一种多功能核蛋白，目前尚不清楚它是否在调节细胞核中针对rna病毒的先天免疫中发挥作用。 这项研究表明，DHX9与体内针对RNA病毒感染的先天免疫应答密切相关。

RNA helicase A/DHX9 (DExH-box helicase 9) binds to and resolves both G4-DNA and G4-RNA and promotes translation by unwinding 5′-UTR G4-RNA structures (Chakraborty and Grosse, 2011; Murat et al ...

2023年8月3日 · DHX9 encodes a BRCA1-interacting nuclear helicase regulating transcription, R-loops, and homologous recombination and exhibits the highest mutational constraint of all DDX/DHX paralogs but remains unassociated with disease traits in OMIM.

2021年9月24日 · We finally obtained DEAH-box helicase 9 (DHX9), a key DNB gene, as a biomarker in adjacent tissues B cells that is indicative of pre-metastasis before lymph node metastasis and could be used as a potential immunotherapy target.