Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. [6] [7] The dickkopf protein encoded by DKK1 is an antagonist of …

Dickkopf (DKK) is a family of proteins consisting of five members as of 2020. That is, vertebrates usually contain five genes that are members of the family. The most well-studied is Dickkopf …

Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with …

2024年5月13日 · Among Wnt modulators, the evolutionary conserved Dickkopf (DKK) proteins, and especially DKK1, the founding member of the family, are the best characterized. DKK1, …

2025年1月30日 · Dickkopf-1 (DKK1) is a soluble inhibitor of the Wnt/β-catenin pathway, primarily recognized for its role in bone homeostasis and cancer-induced osteolytic bone disease 12,13.

Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway. Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal expression of …

2000年4月6日 · Dickkopf-1 (Dkk-1), a secreted glycoprotein, has been found to be necessary and sufficient for inducing amphibian head formation.

2018年9月15日 · Dickkopf-1(DKK-1) has been identified as a secretory protein that can inhibit the Wnt signaling transduction pathway. It is well known that the Wnt signaling pathway plays an …

2025年3月1日 · Here, we propose Dickkopf-1 (DKK1) as a key secretory protein influencing the tumor microenvironment in gefitinib-resistant cancer. Initially identified as an inhibitor of β …

2024年12月24日 · DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, …