2020年5月19日 · Among the top candidates, 2,4-dienoyl-CoA reductase (DECR1), a mitochondrial enzyme involved in polyunsaturated fatty acid (PUFA) degradation, represents a …

2,4 Dienoyl-CoA reductase also known as DECR1 is an enzyme which in humans is encoded by the DECR1 gene which resides on chromosome 8. This enzyme catalyzes the following …

2019年8月19日 · To shed light on PUFA physiology, we have generated a mouse line defective in mitochondrial dienoyl-CoA reductase (Decr), which is a key enzyme required for β-oxidation of …

2024年12月24日 · DECR1 (2,4-Dienoyl-CoA Reductase 1) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-Dienoyl-Coa Reductase Deficiency and Hyperlysinemia. …

2012年8月8日 · Here, we describe the crystal structure of a ternary complex of peroxisomal 2,4-dienoyl CoA reductases (pDCR) with hexadienoyl CoA and NADP, as a prototype for …

2001年8月29日 · Kinetic analysis of recombinant human peroxisomal dienoyl-CoA reductase. In panels A–C, the reductase activity of purified His-tagged human pDCR protein was analyzed …

2020年5月19日 · Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer …

However, many aspects on signals translating PUFA-sensing into body homeostasis have remained enigmatic. To shed light on PUFA physiology, we have generated a mouse line …

2006年12月1日 · The mammalian peroxisomal MFE-1 catalyzes, among the other isomerase reactions, the conversion of 2E,5Z-dienoyl-CoA into 3E,5Z-dienoyl-CoA. The product is a …

2005年1月28日 · We present high resolution crystal structures of human mitochondrial 2,4-dienoyl-CoA reductase in binary complex with cofactor, and the ternary complex with NADP + …