Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. [2] It is the principal metabolite of diphenoxylate. [3][4]: 558 It was first approved in the US in 1978 [5] and in 1980 in the former West Germany. [6]: 485

地芬诺辛是一种止泻药，用作治疗急性非特异性腹泻和慢性功能性腹泻急性加重的辅助药物。 地芬诺辛是一种与阿片类镇痛药哌替啶密切相关的 4-苯基哌啶衍生物。 地芬诺辛单独使用时是美国附表I管制药物，因为它可能导致成瘾。 如果与阿托品联合使用，则它被列为附表 IV 管制药物，阿托品的添加是为了减少故意滥用。 Motofen（R）是硫酸阿托品和盐酸二芬诺辛的商用混合物。 它被美国FDA 批准用于治疗急性和慢性腹泻。 地芬诺辛是止泻药地芬诺酯的活性代谢产物，也与阿 …

2007年7月31日 · Difenoxin is an antidiarrheal agent used as an adjunct for the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea. Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming.

Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination with atropine in the brand mixture Lomotil (R). It works mostly in the periphery and activates opioid receptors in the intestine rather than the central nervous system (CNS). [3]

Find patient medical information for difenoxin-atropine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

2024年12月22日 · Difenoxin and atropine combination medicine is used along with other measures to treat severe diarrhea in adults. Difenoxin helps stop diarrhea by slowing down the movements of the intestines.

2024年4月8日 · Easy-to-read patient leaflet for Difenoxin and Atropine. Includes indications, proper use, special instructions, precautions, and possible side effects.

地芬諾辛 （Difenoxin），商品名 氰苯哌酸。 本藥品被歸類到 胃腸疾病用藥 等藥品分類。 市場上的地芬諾辛 氰苯哌酸 參看 治療胃腸疾病的藥品列表

Difenoxin (Motofen, R-15403) is a 4- phenyl piperidine derivative that is related to the opioid analgesic drug pethidine (meperidine) and more distantly related to alphaprodine and piritramide, and it is an active metabolite of the anti- diarrhoea drug diphenoxylate.

2025年1月7日 · Difenoxin is an antidiarrheal agent used as an adjunct for the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea. Motofen (R) is a combination of atropine, an anticholinergic drug, and difenoxin, an antidiarrheal drug.