目前，DKK1作为经典 Wnt信号通路 的拮抗剂，不仅是肿瘤诊断和预后评价的血清学标志物，更是重要的肿瘤治疗新靶点！ 1. 什么是DKK1？ 2. DKK1拮抗Wnt/β-catenin信号通路的调节机制. 3. DKK1在肿瘤等其它疾病中的作用. 4. DKK1的临床在研药物. 1. 什么是DKK1？ Dickkopf相关蛋白1（Dickkopf-related protein 1，DKK1）是Wnt/B-catenin信号通路的典型抑制剂，属于DKK家族（其余包括 DKK2 、 DKK3 和 DKK4）。 DKK1由人类DKK1基因编码，位于10q11.2，长度 …

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. [5] This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway.

2024年12月24日 · DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Alzheimer's disease and miRNA effects.

Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with a poor prognosis. Our analysis of DKK1 gene profile using data from TCGA also proves the high expression of DKK1 in 14 types of cancers.

Dkk1 is a secretory glycoprotein with two conserved domains rich in cysteine and a connecting region of 50–55 amino acids. The full length of human Dkk1 gene is 1815kb, which is located on chromosome 10q11.2.26. The Dkk1 protein consists of 266 amino acids and its relative molecular weight is about 29 kDa.

Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer’s disease, diabetes, and various cancers.

2025年2月19日 · Dkk-1 serves as a biochemical marker for determining osteoarthritis (OA) severity and might play a potential role in the pathogenesis of the degenerative process of OA. Novel insights into roles for DKK1 in addition to canonical WNT signaling and the mechanism of colon cancer initiating cells transformation.

2004年9月20日 · Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding...

2021年4月14日 · Dickkopf相关蛋白1 (Dkk-1)是一种分泌蛋白，有2个富含半胱氨酸区域，通过对Wnt信号通路的抑制，参与胚胎发育。 所有Dkk-1敲除的纯合子小鼠在出生时都已死亡，这是由于头盖骨和神经嵴的结构有缺陷而导致的，如眼睛、嗅基板、额鼻、下颌等无法发育，以及前脑和 ...

2020年8月2日 · Dkk1 is a secretory glycoprotein with two conserved domains rich in cysteine and a connecting region of 50–55 amino acids. The full length of human Dkk1 gene is 1815kb, which is located on chromosome 10q11.2.26. The Dkk1 protein consists of 266 amino acids and its relative molecular weight is about 29 kDa.