Proven mouse MC38 cell line (KC-2390) for stable MC38 clone expressing exogenous human DLL3. Contact support!

DLL3 expression analysis in B-hDLL3 MC38 cells by flow cytometry. Single cell suspensions from wild-type MC38 and B-hDLL3 MC38 cultures were stained with anti-human DLL3 antibody AMG-757 (in house).

DLL3基因人源化的MC38小鼠结肠癌细胞系*使用本品系发表的文献需注明: MC38-hDLL3 cell line (Cat. NO. NMC-230086) was purchased from Shanghai Model Organisms Center, Inc..

B-hDLL3 MC38 cells (1x10 6) and wild-type MC38 cells (5x10 5) were subcutaneously implanted into B-hCD3E mice (female, 7-week-old, n=6). Tumor volume and body weight were measured twice a week.

Detect of the hDLL3 expression of MC38-hDLL3 cell lines in vivo on hCD3EDG/hDLL3 C57BL/6 mice (Tumors were collected and analysed on Day17). Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。 常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命 …

Antitumor activity of bispecific antibody (BsAb) X in B-hCD3E mice. B-hDLL3 MC38 cells were subcutaneously implanted into B-hCD3E mice (female, 8 week-old, n=6). Mice were grouped when the tumor size was approximately 100 mm 3, at which time they were treated with BsAb X provided by the client with doses and schedules indicated in panel.

前文提到，DLL3是一种抑制性Notch配体，大量研究发现，配体DLL3通过和Notch受体结合，抑制Notch信号，影响相邻细胞之间的通讯，进而调控细胞发育，其具体机制尚不明确。 除了 Notch信号通路，DLL3也在其他信号通路中发挥作用，DLL3通过抑制Notch信号通路，激活脂酰肌醇-3-激酶/丝氨酸-苏氨酸蛋白激B（phosphoinositol-3-kinase/serine-threonine protein kinase B， P13K/Akt）信号传导通路。 DLL3表达上调时，配体Wnt-1和Wnt-4以及Wnt通路的下游靶基 …

MC38 目录号:SCSP-5431 细胞名称: 小鼠结肠癌细胞MC38, 又名MC-38、MCA-38、Mouse Colon 38等细胞描述:MC38 细胞由Tan 等使用1,2- 二甲基肼诱导C57BL/6小鼠产生结肠腺癌后,取 组织再经去除成纤维细胞后获得的结. 肠腺癌上皮细胞系。这是一种在大肠癌研究中广泛使用的小鼠细胞模型,这 些细胞表现出很高的突变速率,使其对免疫检查点抑. 制剂治疗高度敏感。MC38 细胞表达claudin-1 和SATB2等结肠标志物,这对于研究结肠腺癌的基因组和表观基因组以及探寻潜在的. …

MC38细胞是由M.H.Tan等使用1, 2-二甲基肼诱导C57BL/6产生结肠腺癌后，取组织再经去除成纤维细胞后获得的结肠腺癌上皮细胞系。 建系者同时还采用同样诱导方法建立了BALB/c的结肠腺 …