
分子伴侣---蛋白质折叠的促进者 - 知乎 - 知乎专栏
2023年8月9日 · 共同伴侣辅助蛋白(DnaJ/Hsp40)刺激ATP水解为ADP(黄色),导致底物结合域发生巨大的构象变化,导致其构象闭合,底物被锁定在底物结合域;这里促进了适当的折 …
分子伴侣 DnaK 在蛋白质折叠中发挥中枢作用_生物探索
2012年3月9日 · Upon deletion of TF, DnaK interacts increasingly with ribosomal and other small, basic proteins, while its association with large multidomain proteins is reduced. DnaK also …
Hsp70 - Wikipedia
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living …
DnaK Functions as a Central Hub in the - ScienceDirect
2012年3月29日 · DnaK, the major bacterial Hsp70, is one of the most abundant constitutively expressed and stress inducible chaperones in the E. coli cytosol. Yet it is not essential under …
Bacterial Hsp70 resolves misfolded states and accelerates ... - Nature
2020年1月17日 · The ATP-dependent Hsp70 chaperones (DnaK in E. coli) mediate protein folding in cooperation with J proteins and nucleotide exchange factors (E. coli DnaJ and GrpE, …
Protein DnaK - an overview | ScienceDirect Topics
DnaJ proteins are molecular co-chaperones that recruit DnaK family chaperones (heat shock family) to perform functions such as protein folding, protein transport, or remodeling of protein …
Structure of the M. tuberculosis DnaK−GrpE complex reveals how key DnaK ...
2024年1月22日 · Here we report a cryo-EM analysis of GrpE bound to an intact Mtb DnaK, revealing an asymmetric 1:2 DnaK−GrpE complex. The GrpE dimer ratchets to modulate both …
DnaK response to expression of protein mutants is dependent on ...
2022年6月16日 · Our results demonstrate that the initial DnaK response is largely dependent on protein synthesis rate but as the recombinantly expressed protein accumulates and …
Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact ... - PubMed
We investigated the interaction of the major inducible hsp from mammalian (Hsp70) and bacterial (DnaK) species with liposomes. We found that mammalian Hsp70 displayed a high specificity …
DnaK-DnaJ-GrpE分子伴侣的温度控制活性:热休克期间和之后的 …
来自大肠杆菌的热休克蛋白DnaK,DnaJ和GrpE(KJE)构成三组分分子伴侣系统,该分子伴侣系统可防止变性蛋白质聚集并以ATP依赖性方式协助蛋白质重新折叠。