DNA Methyltransferases (DNMTs), DNA Damage Repair, and …
The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation, …
The DNA methyltransferase family: a versatile toolkit for ... - PubMed
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
The DNA methyltransferase family: a versatile toolkit for ... - Nature
2017年10月16日 · The DNA methyltransferases (DNMTs) are a conserved family of cytosine methylases with a key role in epigenetic regulation. DNMT activity is highly regulated.
Tissue-specific roles of de novo DNA methyltransferases
2025年1月17日 · DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, …
The Role of DNMT Methyltransferases and TET Dioxygenases in …
2024年9月4日 · This review deals with the functional characteristics and biological roles of enzymes participating in DNA methylation and demethylation as key factors in epigenetic …
The Role of DNMT Methyltransferases and TET Dioxygenases in …
2024年9月4日 · DNA methyltransferases 3 (DNMT3A and DNMT3B) can attach the methyl group to atom C5 of cytosine in CpG dinucleotides de novo, while DNMT1 has a preference for …
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in ...
2023年2月4日 · Here, we show that protein S-nitrosylation of a cysteine residue in DNMT3B attenuates DNMT3B enzymatic activity and consequent aberrant upregulation of gene …
Genomic profiling of DNA methyltransferases reveals a role for …
2015年1月21日 · DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA …
Tissue-specific roles of de novo DNA methyltransferases
2025年1月17日 · DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, …
DNMTs and Impact of CpG Content, Transcription Factors, Consensus ...
DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the …