2020年6月8日 · Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent and combined effects...

2016年10月19日 · These observations demonstrate that Tet and Dnmt act antagonistically to regulate DNA methylation at the Lefty genes, ensuring their proper expression to restrict Nodal signalling during...

2020年10月1日 · The results showed that a vicious combination of TET repression, due to NF-κB activation, and DNMT activation, due to NO production, is responsible for aberrant methylation induction in human tissues.

2024年9月4日 · By combining the up-to-date information on the dysfunction of various enzymes that control the DNA "methylome" in the human body, we hope not only to draw attention to the importance of the maintenance of a required DNA methylation level (ensuring epigenetic regulation of gene expression and normal functioning of the entire body) but also to hel...

2023年5月22日 · Here, we establish a system of simultaneous inactivation of multiple endogenous genes in zygotes through screening for base editors that can efficiently introduce a stop codon. Embryos with...

2022年10月1日 · Here, we revealed that the main DNA-binding domain of TET1 contains more positive charges by using charge reduction of amino acid alphabet, followed by DNMT3A and DNMT3B. The genome-wide binding profiles showed that TET1 prefers binding to the proximal promoters and CpG islands compared with DNMT3A/B.

It has been reported that DNA methyltranseferases (Dnmts) function as methylation writers and maintainers, and ten-eleven translocation (Tet) acts as a methylation eraser (Fig. 1). Regulation of DNA methylation has been widely examined in pluripotent stem cells, including embryonic stem …

在人体细胞中执行此类过程的酶组仅限于两个家族的代表，即 DNMT（DNA 甲基转移酶）和 TET（DNA 双加氧酶）。 该综述提供了当今已知的有关这些家族中每个功能重要成员的详细信息，并描述了哺乳动物体内的催化活性和作用，同时还提供了这些酶的表达和/或活性 ...

2018年7月12日 · Here we demonstrate that DNMT3A and TET1 function in a complementary and competitive manner in mouse embryonic stem cells to mediate proper epigenetic landscapes and gene expression.

In biological settings, chronic inflammation can induce both TET repression and increased DNMT activity. This vicious combination was considered to cooperatively induce aberrant DNA methylation, even in genomic regions resistant to DNA methylation induction.