2021年9月1日 · Penicillinase-producing N. gonorrhoeae (PPNG) isolates with high-level plasmid-mediated resistance to penicillin were first isolated in 1976 [2, 3] and have subsequently been spreading worldwide [4]. Penicillin resistance in PPNG is mediated by the β-lactamase-encoding gene bla TEM carried on several related

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淋球菌可通过质粒介导产生青霉素酶（β-内酰胺酶），使青霉素类失去活性，这一类淋球菌被称为ppng。 目前，青霉素已不用于我国淋病的治疗，PPNG的鉴定仅用于我国的淋球菌耐药监测项目。

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PPNG isolates expressing TEM-135 beta-lactamase exhibited significantly higher penicillin MIC values than TEM-1 PPNG isolates. PPNG isolates showed high genetic diversity and high proportions...

Penicillinase-producing Neisseria gonorrhoeae (PPNG) causes the same clinical picture as nonpenicillinase-producing gonococci. Definitive identification depends on demonstration of penicillin resistance followed by tests for the beta-lactamase enzyme (penicillinase).

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In this study, we developed and validated a real-time PCR assay for the detection of penicillinase-producing N. gonorrhoeae (PPNG) in noncultured clinical samples with the aim of enhancing penicillin resistance surveillance.

Transmission of spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae (PPNG) has been documented for the first time. Between August 1982 and January 1983, 27 cases of spectinomycin-resistant PPNG infection were reported by U.S. Air Force Facilities in the Pacific.