A Product Information File (PIF), in the context of drug safety, is a comprehensive collection of data and documents pertaining to a pharmaceutical product. This file is an essential element in the regulatory submission process and ongoing product maintenance.

2021年9月21日 · Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence.

2022年7月29日 · For optimal drug delivery, dry powder inhalers (DPIs) depend on the patient’s peak inspiratory flow (PIF) and the internal resistance of the device to create turbulent energy and disaggregate the powder. A suboptimal PIF may lead to ineffective drug inhalation into the lungs.

2023年4月3日 · patient’s peak inspiratory flow (PIF) is sufficient for effective DPI drug delivery, by maximally inspiring though a resistance appropriate to the DPI being used by the patient. It has also been suggested that there may be a suboptimal PIF …

2022年5月26日 · Taking into consideration that DPIs are breath-actuated devices, it is crucial that patients can generate a sufficient peak inspiratory flow rate (PIF) to enable optimal drug delivery to the ...

2018年12月13日 · Peak inspiratory flow (PIF) as generated through the resistance of a dry powder inhaler (DPI) device is a critical patient-dependent maneuver impacting the success of DPI medication delivery. Despite its importance, it is not routinely measured in clinical practice.

Introduction: Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence.

We believe that peak inspiratory flow (PIF), de fined as the maximum air flow generated during inhalation in liters per minute against the simulated resistance of a DPI (PIFr), meets the criteria as a therapeutic biomarker.

Drug delivery and lung deposition from a dry powder inhaler (DPI) are dependent on the peak inspiratory flow (PIF) through the DPI. Therefore, when prescribing a DPI, it is important to know whether a child is able to generate sufficient PIF through a particular device.

2022年2月16日 · It is important to assess PIF against the simulated resistance of a DPI to ensure that a patient is capable of achieving optimal drug deposition; however, this is not commonly carried out in clinical practice [12,13].