Wholesale-level DTOs, especially Mexican DTOs, constitute the greatest drug trafficking threat to the United States. These organizations derive tens of billions of dollars annually from the trafficking and abuse of illicit drugs and associated activities.

Drug trafficking organizations from nations with lesser, or no drug laws emerged with the opportunity to make large profits from illegal trafficking into the United States. These organized crime syndicates would use any means necessary to exploit the weak border protection of the US.

The DTO viewer is an interactive visual representation of the Drug Target Ontology, each circle onclick can expand or collapse the nodes.

墨西哥9个主要DTO，包括蒂华纳，锡那罗亚，华雷斯，海湾，泽塔斯，哈利斯科新一代集团 etc. 尽管如此，“卡特尔”这个名词还是在某种程度上可以反映贩毒集团的实际运转方式。

2018年2月15日 · The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous ...

DTO is a novel semantic framework to formalize knowledge about drug targets and is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from …

By providing a semantic framework of diverse information related to druggable proteins, DTO facilitates the otherwise challenging integration and formal linking of heterogeneous and diverse data important for drug discovery. DTO is particularly relevant for big data, systems-level models of diseases and drug action as well as precision medicine.

2017年11月9日 · DTO classifies the four major drug target protein families, GPCRs, kinases, ion channels and nuclear receptors, based on phylogenecity, function, target development level, disease association, tissue expression, chemical ligand and substrate characteristics, and target-family specific characteristics.

Drug Target Ontology (DTO) is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources.

Drug Target Ontology (DTO) uses formal description logic to provide a classification of (protein) drug targets based on function and phylogenetics. Rich annotations of (protein) drug targets along with other chemical, biological, and clinical classifications and relations to diseases and tissue expression are also formally described in DTO ...