Dynamin is a GTPase protein responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs.

Jan 11, 2012 · Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events.

Dynamins are associated with diverse cellular processes, including the release of transport vesicles [as in clathrin-mediated endocytosis (CME)], fusion and fission of mitochondria, division of chloroplasts and peroxisomes, cell division, and resistance to viral infections.

Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and possibly vesicle trafficking in and out of the Golgi.

Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton.

Feb 1, 2004 · Classical dynamins belong to a superfamily that includes dynamin-like proteins, optic atrophy 1 (OPA1), mitofusin and Mx proteins. On the basis of sequence homology, domain structure and...

4 days ago · The dynamin superfamily GTPases are key membrane remodelers in cells. As a recently identified member, RNF112 is essential for functional synapses by regulating endosome and mitochondrial morphology, but its mechanisms remain obscure. This study reports the crystal structures of modified RNF112 in different stages of GTP hydrolysis and reveals its unique …

Dynamin - a member of the GTP-ase protein family - is essential for many intracellular membrane trafficking events in multiple endocytic processes. The unique biochemical features of dynamin - especially its propensity to assemble - enable severing the nascent vesicles from the membrane.

Dynamin, the founding member of a family of dynamin-like GTPases (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events.

Apr 23, 2018 · Here, we describe the various structural, biophysical, and biochemical properties of the dynamin superfamily, which reflect their distinct functions in the cell, and point toward future directions that may enable a more comprehensive understanding of these fascinating mechanoenzymes.