
DYRK2 Gene - GeneCards | DYRK2 Protein | DYRK2 Antibody
2024年12月24日 · DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Diseases associated with DYRK2 include Intellectual Developmental Disorder, Autosomal Dominant 7 and Down Syndrome. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.
Emerging roles of DYRK2 in cancer - PMC - PubMed Central (PMC)
Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor across various cancers triggering major antitumor and proapoptotic signals in breast, colon, liver, ovary, brain, and lung cancers, with lower DYRK2 expression correlated with poorer prognosis in …
Protein kinase DYRK2 is a scaffold that facilitates assembly
2009年3月15日 · Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP proteins...
DYRK2 dual specificity tyrosine phosphorylation regulated kinase …
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues.
Updating dual-specificity tyrosine-phosphorylation-regulated …
Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease.
The DYRK Family of Kinases in Cancer: Molecular Functions and ...
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes.
Selective inhibition reveals the regulatory function of DYRK2 in ...
2022年4月19日 · The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function.
DYRK2 controls a key regulatory network in chronic myeloid
2020年10月16日 · In this review, we briefly discuss molecular maintenance in leukemia stem cells in chronic myeloid leukemia and provide a more in-depth discussion of the dual-specificity kinase DYRK2, which...
Protein kinase DYRK2 is an E3-ligase specific molecular assembler
In this study, we discover that a protein kinase DYRK2 has unexpected role as a molecular assembler for an E3-ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP proteins (EDVP complex).
Selective inhibition reveals the regulatory function of DYRK2 in ...
2022年4月19日 · We have recently identified LDN192960 as a selective DYRK2 inhibitor and showed that LDN192960 could alleviate multiple myeloma and triple-negative breast cancer progression by inhibiting DYRK2-mediated proteasome phosphorylation (Banerjee et al., 2019).
Multiple functions of DYRK2 in cancer and tissue development
DYRK2, a member of the class II DYRK family protein, is a key regulator of p53, and phosphorylates it at Ser46 to induce apoptosis in response to DNA damage. Moreover, recent studies have uncovered that DYRK2 regulates G1/S transition, epithelial-mesenchymal-transition, and stemness in human cancer cells.
Updating dual-specificity tyrosine-phosphorylation-regulated kinase …
Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease.
Roles of dual specificity tyrosine-phosphorylation-regulated kinase …
DYRK2 regulates neuronal morphogenesis (e.g., axon growth and branching) by phosphorylating cytoskeletal elements (e.g., doublecortin). Comparative data reveals that it is involved in the development of olfactory and visual systems, the spinal cord and possibly the cortex.
DYRK2 dual specificity tyrosine phosphorylation regulated kinase …
2024年1月26日 · DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
Emerging roles of DYRK2 in cancer - ScienceDirect
2021年1月1日 · Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor across various cancers triggering major antitumor and proapoptotic signals in breast, colon, liver, ovary, brain, and lung cancers, with lower DYRK2 expression correlated with poorer prognosis in patients.
Curcuminoids WM03 inhibits ovarian cancer cisplatin-resistant …
2 天之前 · DYRK2 is a serine/threonine kinase that targets Akt, a key mediator of cell survival and growth. When activated, Akt promotes cell proliferation and inhibits apoptosis, contributing to cancer development and progression. The downstream effector of Akt in this pathway is Ki67, a protein that is widely used as a marker of cell proliferation. ...
Engagement of DYRK2 in proper control for cell division
2015年3月3日 · Recent studies have shown that DYRK2 down-regulates key molecules on cell cycle control. This review mainly highlights the DYRK2 function during cell division. In addition, we summarize tumor suppressive role of DYRK2 in cancer cells and discuss future research directions for DYRK2 toward the novel cancer therapies.
Updating dual-specificity tyrosine-phosphorylation-regulated kinase …
Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease.
Functional Roles of DYRK2 as a Tumor Regulator - PubMed
2023年10月23日 · The dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) regulates the induction of apoptosis and DNA repair, metastasis inhibition, cell cycle G1/S transition, protein scaffold stability for E3 ligase complexes, and embryogenesis.
Roles of dual specificity tyrosine-phosphorylation-regulated kinase …
2022年9月8日 · DYRK2 regulates neuronal morphogenesis (e.g., axon growth and branching) by phosphorylating cytoskeletal elements (e.g., doublecortin). Comparative data reveals that it is involved in the development of olfactory and visual systems, the spinal cord and possibly the …
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