2023年6月13日 · Specifically, E2F1, E2F2, and E2F3 enhance CDK1 transcription by binding to the positive-acting E2F site in the CDK1 promoter, which results in increased CDK1 …

在e2f的靶点中有两个e型细胞周期蛋白(e1和e2，统称为细胞周期蛋白e)，它们结合并激活cdk2。cyclin e-cdk2负责完成rb1的磷酸化，通过释放更多的e2f，促进细胞进入s期所需的蛋白质的合成。

2022年10月10日 · Inhibition of CDK1/CDK2 prevented DNA damage induced by E2F loss, suggesting that E2F1/E2F2 safeguard genome integrity by restraining CDK1/CDK2 activity. …

在 g1 阶段，抑癌基因 rb 结合并抑制转录因子 e2f。 在 G1 末期被周期素依赖性激酶 (CDK) 磷酸化的 Rb 会诱使 Rb 分裂，并允许 E2F 介导的 S 期促进基因的转录。

2016年3月23日 · The results indicate that E2F1 and CDK1 take part in the apoptosis of SGCs, and the E2F1-CDK1 pathway might play a significant role in SGC apoptosis. In our study, the …

2019年5月3日 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, …

We identify CCNE1 gain and RB1 loss as mechanisms of resistance to CDK4/6 inhibition, whereas receptor tyrosine kinase (RTK) and RAS signaling is associated with CDK2 inhibitor …

最后，在g1晚期，转录因子e2f激活早期有丝分裂抑制因子 emi1的转录，该蛋白可以作为假底物抑制apc/c的活性。 图6 APC/C-Cdh1可以抑制细胞进入S期， 从而在G1期滞留

2022年10月10日 · Here we present evidence that combined silencing of E2F1 and E2F2 results in inappropriate CDK1 activation during S phase, concomitantly with reduced expression of …

2010年1月1日 · In this review, we summarize the effects of CDKs on E2F1 activity and describe a model that may explain the role of CDK8–CycC in E2F regulation. Since CDKs can both …