E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.

细胞周期蛋白依赖性激酶 (CDK)-RB-E2F 调控轴组成了驱动细胞周期进程、决定基因组复制的时间和准确性、并确保遗传物质准确传递的核心转录机制。 该调控轴的最终效应子是编码转录激活因子和抑制因子的8个不同 E2F 基因家族的成员（E2F1-8）。 E2F 转录活性在整个细胞周期中通过转录和翻译调控、翻译后修饰、蛋白质降解、与辅因子的结合和亚细胞定位等过程受到严格调控。 该调控轴的一个或多个关键成分 (CDKs, cyclins, CDK inhibitors and the RB family of proteins) …

e2f是一组编码高等真核生物 转录因子家族的基因。其中三个是激活剂：e2f1,e2f2和e2f3a。其他六个充当抑制剂：e2f3b,e2f4,e2f5,e2f6,e2f7a,e2f7b和e2f8。它们都参与哺乳动物细胞中dna的细胞周期调控和合成。

2019年5月3日 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, how misexpression...

2015年12月3日 · Our results represent the first crystal structure of an E2F protein with two DBDs, and reveal the mechanism by which atypical E2Fs can repress canonical E2F target genes and exert their...

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required.

2003年4月1日 · In mammalian cells, the E2F family of transcription factors plays a pivotal role in regulating the expression of genes involved in the G1/S transition and DNA synthesis. In turn, E2F activity is controlled primarily by the retinoblastoma (pRB) family of proteins.

2019年9月18日 · In this study, we show that E2F1 regulates gene expression for HR factors and DNA replication. We also demonstrate an essential role for the HR pathway in colon cancer progression.

Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development.

2015年12月3日 · Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors. To understand the mechanism of repression, we have resolved the structure of E2F8 in complex with DNA at atomic resolution.