In summary, current data suggest an overall decrease in EAAT1 mRNA in affective disorders, while an increase in EAAT1 mRNA and decrease in EAAT1 protein is associated with schizophrenia; results which are further complicated by suicide completion and medication use.

2010年3月16日 · Excitatory amino acid transporters (EAATs) appear to participate in the pathogenesis of neuropathic pain. The present study was performed to evaluate the effects of the tricyclic antidepressant amitriptyline on the expressions of EAATs in neuropathic pain rats.

EAAT1 is highly expressed in the neocortex and cerebellum, especially in astrocytes [2,19]; EAAT2 is the main glutamate transporter found in the forebrain; it is abundantly expressed in astrocytes and in a limited extent also on presynaptic nerve terminals [2,20].

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels at low levels. In physiology, this is essential for the rapid ...

2024年11月26日 · 稳健的EAAT表达，特别是EAAT1，是成人神经干细胞（NSC）表型的广泛使用的标志物（Rieskamp等人，2023）。 我们提供几种经KO验证的抗体用于检测EAAT1。 EAAT1产品

2015年2月1日 · Recently identified physiological functions of EAATs are presented. The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the …

2022年1月6日 · Excitatory amino acid transporters (EAATs) optimize the temporal resolution and energy demand of mammalian excitatory synapses by quickly removing glutamate from the synaptic cleft into surrounding neuronal and glial cells …

2019年12月15日 · Pharmacological inhibition or gene knock-down of spinal GluTs can induce/aggravate pain, whereas enhancing expression of GluTs by viral gene transfer can mitigate chronic pain. Thus, functional up-regulation of GluTs is turning into a prospective pharmacotherapeutic approach for the management of chronic pain.

2017年4月19日 · Here we present crystal structures of a thermostabilized human SLC1 transporter, the excitatory amino acid transporter 1 (EAAT1), with and without allosteric and competitive inhibitors bound.

2018年6月28日 · This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders.