Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). [1] It is the only EBV protein found in all EBV-related malignancies. [2][3] It is important in establishing and maintaining …

Epstein-Barr nuclear antigen 1 (EBNA1) was the first Epstein-Barr virus (EBV) protein detected and is the most widely studied [1]. EBNA1 is expressed in both latent and lytic modes of EBV infection, although it has mainly been studied in latency, where it plays multiple important roles.

2023年4月12日 · Here we show that the sequence-specific DNA-binding domain of EBNA1 binds to a cluster of tandemly repeated copies of an EBV-like, 18-base-pair imperfect palindromic sequence encompassing a...

Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA ...

1994年10月17日 · Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as …

The Epstein–Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis has remained enigmatic. We show that ...

2018年4月6日 · The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby …

2019年9月11日 · The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA damage and...

Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) is an essential viral protein and is expressed in all EBV-associated tumours as well as all latency programs of the virus, except perhaps for latency 0. It exerts essential functions in viral DNA replication and the episomal genome maintenance, achieved through sequence-specific DNA binding.

2021年1月25日 · EBNA1是这些癌症的一个有吸引力的靶点，这是因为它在所有EBV相关肿瘤中表达，在 肿瘤 发生过程中具有重要的活性，而且在人体内没有类似的蛋白。 论文通讯作者、威斯达研究所基因表达与调控项目负责人Paul M. Lieberman博士说，“我们发现了EBNA1的一种酶活性，这是以前从未描述过的，尽管我们为描述这种蛋白的特性付出了巨大的研究努力。 我们发现EBNA1具有在DNA复制末期让单链DNA发生交联并产生切口的隐性能力。 这可能对其他具有 …