2024年12月24日 · EBP (EBP Cholestenol Delta-Isomerase) is a Protein Coding gene. Diseases associated with EBP include Mend Syndrome and Chondrodysplasia Punctata 2, X-Linked Dominant. Among its related pathways are superpathway of cholesterol biosynthesis and Cholesterol metabolism.

Emopamil binding protein is a protein that in humans is encoded by the EBP gene, located on the X chromosome. [5] The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil, resulting in its discovery and given name.

The EBP gene provides instructions for making an enzyme called 3β-hydroxysteroid-Δ8,Δ7-isomerase. This enzyme is responsible for one of the final steps in the production of cholesterol. Specifically, it converts a molecule called 8 (9)-cholestenol to lathosterol. Other enzymes then modify lathosterol to produce cholesterol.

2018年9月20日 · HGNC Approved Gene Symbol: EBP. The EBP gene encodes an integral membrane protein located mainly in the endoplasmic reticulum that functions as a key enzyme in the final steps of the sterol biosynthesis pathway (summary by Hartill et al., 2014).

2020年7月27日 · ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proteins, which regulate proliferation 1, and it is an evolutionarily conserved, ubiquitously expressed, and multifunctional...

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil.

2024年12月27日 · EBP adopts an unreported fold involving five transmembrane-helices (TMs) that creates a membrane cavity presenting a pharmacological binding site that accommodates multiple different ligands. Mutagenesis studies on specific residues abolish the isomerase activity and decrease the multidrug binding capacity.

2025年2月9日 · The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil.

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

2021年1月14日 · The emopamil binding protein (EBP) is an important enzyme participating in the final steps of cholesterol biosynthesis in mammals. A predictive gene EBP-like, which encodes the protein with a high identity to human EBP, was found in chicken genome. No regulatory mechanisms and biological functions of EBP-like have