2024年4月10日 · Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a gamma herpes virus that occurs only in humans. Laboratory testing can help distinguish whether someone is susceptible to EBV infection or has a recent or past infection.

2023年7月12日 · The Epstein-Barr virus test checks your blood for antibodies. After you are first exposed to EBV, there is an incubation period of several weeks before you start to have symptoms.

Epstein-Barr nuclear antigen 1 (EBNA1) was the first Epstein-Barr virus (EBV) protein detected and is the most widely studied [1]. EBNA1 is expressed in both latent and lytic modes of EBV infection, although it has mainly been studied in latency, where it plays multiple important roles.

Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). [1] It is the only EBV protein found in all EBV-related malignancies. [2][3] It is important in establishing and maintaining …

Serological tests for antibodies specific for Epstein-Barr virus (EBV) antigens are frequently used to define infection status and for the differential diagnosis of other pathogens responsible for mononucleosis syndrome.

Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA ...

2019年6月11日 · The EBV (Epstein Barr) Nuclear Antigen Antibodies, IgG test looks for a type of antibody which the body typically develops in response to Epstein-Barr Virus. EBNA antibodies usually appear 2-4 months after infection and persist for the life of the person.

2025年2月9日 · EBV编码的核抗原 (如EBNA1、EBNA2、EBNA3家族) 和膜蛋白 (如LMP1、LMP2A) 在细胞转化和肿瘤发生中起重要作用。 例如，LMP1通过激活NF-κB信号通路促进细胞增殖和存活，而EBNA2则通过激活细胞和病毒基因促进细胞转化。 EBV与肿瘤的关系. EBV与多种淋巴瘤 (如Burkitt淋巴瘤、霍奇金淋巴瘤、弥漫大B细胞淋巴瘤等) 和上皮性癌症 (如鼻咽癌、胃癌等) 密切相关。 在这些肿瘤中，EBV的潜伏感染模式和表达的病毒蛋白不同，但其在肿瘤发生中 …

2021年1月25日 · EBV在B淋巴细胞中建立终生的、潜伏的感染，可促使不同癌症类型的发展，包括伯基特淋巴瘤、鼻咽癌（NPC）和霍奇金淋巴瘤。 EBNA1是这些癌症的一个有吸引力的靶点，这是因为它在所有EBV相关肿瘤中表达，在 肿瘤 发生过程中具有重要的活性，而且在人体内没有类似的蛋白。 论文通讯作者、威斯达研究所基因表达与调控项目负责人Paul M. Lieberman博士说，“我们发现了EBNA1的一种酶活性，这是以前从未描述过的，尽管我们为描述这种蛋白的特 …

2023年8月7日 · EB病毒 (Epstein－Barr virus, EBV)为疱疹病毒科，疱疹病毒IV型，是一种嗜人类淋巴细胞的疱疹病毒。 EBV是双链DNA病毒，基因组长约172kb，在病毒颗粒中呈线性分子，进入受感染细胞后，其DNA发生环化并能自我复制。