T cell epitope screening of Epstein-Barr virus fusion protein gB
2021年4月26日 · Glycoprotein B (gB) is an essential fusion protein for the Epstein-Barr virus (EBV) infection of both B cells and epithelial cells and is thus a promising target antigen for a …
Structure of a trimeric variant of the Epstein–Barr virus ... - PNAS
2009年2月24日 · Here, we report the crystal structure of the secreted EBV gB ectodomain, which forms 16-nm long spike-like trimers, structurally homologous to the postfusion trimers of the …
Epstein Barr Virus: Development of Vaccines and Immune Cell …
These data suggest that the combination of EBV gH/gL, gB and gp350 could be an ideal EBV prophylactic vaccine that can elicit markedly high EBV neutralizing activity with the potential to …
Mapping regions of Epstein–Barr virus (EBV) glycoprotein B (gB ...
2011年4月25日 · Glycoproteins gB and gH/gL are required for entry of Epstein–Barr virus (EBV) into cells, but the role of each glycoprotein and how they function together to mediate fusion is …
Protective anti-gB neutralizing antibodies targeting two vulnerable ...
2022年8月9日 · Glycoprotein B (gB) is the primary fusogen essential for EBV entry into host cells. Here, we isolated two EBV gB-specific neutralizing antibodies, 3A3 and 3A5; both effectively …
靶向EB病毒-细胞膜融合过程核心糖蛋白gB的特异性中和抗体研究
2023年5月31日 · 研究者筛选得到了两株靶向ebv gb蛋白的中和抗体 3a3 和 3a5 ，并验证了其体内保护效果，通过以双荧光素酶报告系统为基础的细胞融合模型探究了3a3及 ...
Characterization of EBV gB indicates properties of both class I and ...
2007年11月10日 · We provide evidence that recombinant EBV gB ectodomains have features that biochemically relate gB to other fusogenic proteins and we identified residues that form …
<br>GB 和 gH/gL 融合机制：预防 Epstein-Barr 病毒感染的疫苗的 …
由EBV gB和gH/gL构成的核心膜融合机制，由于其在病毒与靶细胞膜融合中的重要作用，是上皮EBV感染中和抗体的重要靶点。 本文综述了EBV感染的主要模式、核心融合机制gB和gH/gL的 …
A potent and protective human neutralizing antibody targeting …
2021年11月16日 · Here, we isolate EBV gH/gL-specific antibodies from an EBV-infected individual. One antibody, 1D8, efficiently neutralizes EBV infection of two major target cell …
A gB nanoparticle vaccine elicits a protective neutralizing antibody ...
2023年11月8日 · The detailed investigation into the neutralizing efficacy and passive protection against EBV virus in mice demonstrates that gB is not only suitable as an antigen for vaccine …
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