Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells, [5] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling). [6] . The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1.

Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has a wide range of roles both physiologically and pathologically. In recent years, there has been a focus on the contribution of ET-1 to disease.

2024年12月24日 · EDN1 (Endothelin 1) is a Protein Coding gene. Diseases associated with EDN1 include Question Mark Ears, Isolated and Auriculocondylar Syndrome 3. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

There are three types of endothelins, i.e., EDN1 (Endothelin 1), EDN2 (Endothelin 2), and EDN3 (Endothelin 3) encoded by chromosomes 6, 1 and, 20, which are produced by sequential cleavage of the respective endothelin precursors.

2013年7月25日 · ET1 signalling promotes cell proliferation, survival, epithelial-to-mesenchymal transition, neovascularization, response of immune cells and drug resistance in a context-dependent manner. Hence,...

Since its discovery over 20 years ago endothelin-1 (ET-1) has been implicated in a number of physiological and pathophysiological processes. Its role in the development and progression of chronic kidney disease (CKD) is well established and is an area of ongoing intense research.

2020年9月26日 · EDN1 caused potent retinal vasoconstriction beginning rapidly after injection and lasting up to 3 h (arrowheads indicate areas of vasoconstriction at 3 h post-EDN1).

2021年1月9日 · The enhanced expression of EDN1 can promote a self-amplifying vicious cycle potentiating ET-1 axis-dependent adverse outcomes. This observation is supported by previous studies reporting that primary ovarian cancer cells release ET-1 in their conditioned media to a concentration that is within the biologically effective range for this peptide ...

2023年11月2日 · Compared with all other mRNA-encoding vasoactive peptides present in human endothelial cells, EDN1 mRNA is the most abundant by an order of magnitude (Fig. 3a). The peptide is expressed by ...

2024年12月10日 · Concomitant endothelin-1 overexpression in lung transplant donors and recipients predicts primary graft dysfunction. Salama M, et al. Am J Transplant, 2010 Mar. PMID 20055806. The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis. Swigris JJ, et al. BioDrugs, 2010 Feb 1. PMID 20055532, Free PMC Article. What's a GeneRIF?