The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1. EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer through a coiled coil .

而早期内体抗原1（EEA1）是一种与Rab5相互作用的蛋白。 它是一种分子量为162 kDa的蛋白并参与内涵体运输。 所以也是内涵体的常用marker。

早期内切体抗原1（eea1）是一种早期内切体蛋白，包含n-末端锌指基序、富含半胱氨酸的c-末端金属结合指和n-糖基化、磷酸化和n-肉豆蔻酰化的多个位点。

2024年12月24日 · EEA1 (Early Endosome Antigen 1) is a Protein Coding gene. Diseases associated with EEA1 include Subacute Cutaneous Lupus Erythematosus and Cutaneous Lupus Erythematosus. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Innate Immune System.

EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of incoming endocytic vesicles before fusion with early endosomes. Because of the presence of complex endosomal pathways in polarized and nonpolarized cells, we have examined the distribution of EEA1 in diverse cell types.

启用 1-磷脂酰肌醇结合活性； GTP 依赖性蛋白结合活性；和蛋白质同二聚化活性。 参与内吞作用；囊泡融合；和病毒 RNA 基因组复制。 位于胞质溶胶和早期内体。 是质膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月] Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication.

Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells …

1995年6月2日 · We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated with early endosomes since it co-localizes by immunofluorescence with the transferrin receptor and with Rab5 but not with Rab7.

2021年12月16日 · 早期内切体抗原1（eea1）是一种早期内切体蛋白，包含n-末端锌指基序、富含半胱氨酸的c-末端金属结合指和n-糖基化、磷酸化和n-肉豆蔻酰化的多个位点。

EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to …