2017年10月13日 · EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of incoming endocytic vesicles before fusion with early endosomes. Because of the presence of complex endosomal pathways in polarized and nonpolarized cells, we have examined the distribution of EEA1 in diverse cell types.

Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells …

EEA1 is a membrane bound, endosome fusion-promoting protein and an effector of the small GTPase Rab5 that regulates early endocytosis events (33, 34). Together, these proteins enable early endosome formation. Because EEA1 is not found in other endosomal compartments, it has become a de facto marker of the early endosome. Recent evidence infers ...

早期内切体抗原1（eea1）是一种早期内切体蛋白，包含n-末端锌指基序、富含半胱氨酸的c-末端金属结合指和n-糖基化、磷酸化和n-肉豆蔻酰化的多个位点。

We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated with early endosomes since it co-localizes by immunofluorescence with the transferrin receptor and with Rab5 but …

2024年12月24日 · EEA1 (Early Endosome Antigen 1) is a Protein Coding gene. Diseases associated with EEA1 include Subacute Cutaneous Lupus Erythematosus and Cutaneous Lupus Erythematosus . Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Innate Immune System .

启用 1-磷脂酰肌醇结合活性； GTP 依赖性蛋白结合活性；和蛋白质同二聚化活性。 参与内吞作用；囊泡融合；和病毒 RNA 基因组复制。 位于胞质溶胶和早期内体。 是质膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月] Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication.

2011年1月28日 · Using cell fractionation and fluorescence methods, we demonstrate that the early endosomal antigen-1 (EEA1)-positive endosomes are a major site of Ang II-induced Akt activation. Akt moves to and is activated in EEA1 endosomes.

2020年5月1日 · EEA1-vesicles directly fuse with incoming EGF/EGFR-vesicles into hybrid endosomes with separated EEA1- and EGFR-domains, thus providing a platform for rapid achievement of an excess of surface-derived membrane that is …

EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of incoming endocytic vesicles before fusion with early endosomes. Because of the presence of complex endosomal pathways in polarized and nonpolarized cells, we have examined the distribution of EEA1 in diverse cell types.