2015年10月1日 · Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of cell survival and metabolism. Concomitantly, ligand-bound EGFR is incorporated into clathrin-coated pits--membrane structures containing clathrin and other pro …

2019年7月25日 · Growth factor-activated PI3K/Akt signalling pathway regulates leucine transport through LAT3 in prostate cancer cell lines. These data support a direct link between growth factor and amino acid uptake, providing a mechanism by which the cells rapidly coordinate amino acid uptake for cell growth.

2022年11月29日 · The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this pathway, i.e., the docking protein Gab1, the PI-3K/AKT pathway in epithelial cells is regulated by t …

Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. EGF activation of the EGFR induces receptor dimerization and transphosphorylation of the C-terminal domain.

We investigated the role of AKT in EGFR trafficking and discovered a negative feedback loop in which EGF-mediated activation of AKT promotes EGFR progression through the early endosomes and EGFR degradation by activating PIKfyve.

Considering GH modulation of EGFR expression and activation, the relevance of the PI3K-Akt signaling in cell survival and in the pathogenesis of cancer, as well as the implication of GH and EGFR in the development of hepatocarcinoma, the objective of this study was to analyze the modulatory role of GH overexpression in EGF-induced PI3K-Akt ...

bdnf 对 egf 诱导的 nspc 增殖和迁移的增强作用被 pi3k 抑制剂 ly294002 消除。这些发现表明 bdnf 通过 pi3k/akt 途径促进 egf 诱导的 nspc 增殖和迁移，不仅为 egf 诱导的神经发生的机制提供了重要的见解，还提供了治疗脑损伤的潜在神经元替代策略。

We propose a positive feedback mechanism in which exocytosis regulates a key signaling pathway downstream of EGFR. The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling.

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of cell survival and metabolism.

5 天之前 · In cells, EGF stimulation elicits Akt signaling, which recruits Acapin to the lamellipodium membrane via phosphorylation of Acapin at its Ser247 residue and enhances the binding of Acapin to ACAP4 to elevate the ARF6-GTP level. Therefore, Acapin is required for efficiently stimulating cell migration by EGF–Akt signaling. Together, our results ...