2021年6月11日 · In this work, we decided to test single mutants of one ligand, EGF, by identifying and modifying sites responsible for a divergent function among paralog ligands. Recent studies have shown that some EGF residues such as Arg-41 and Leu-47 are highly conserved and important for high binding affinity to the EGFR (10).

1982年1月1日 · Epidermal growth factor (EGF), a single chain polypeptide, belongs to a new class of cytomodulatory factors that are hormone-like in their biological potencies. EGF-like polypeptides may be produced during tumorigenesis by the reactivation of genes that are expressed only during development of the embryo.

the binding of MSA and EGF to normal mink lung cells and mink lung cells transformed by murine sarcoma virus was compared after incubation for different times ranging

1980年9月25日 · Vitamin K3 modulation of EGF-receptor interaction is a temperature- and time-dependent phenomenon. EGF-receptor interaction is also significantly modulated by 1,4-naphthoquinone, 1,4-benzoquinone, and phenanthrenequinone but not by other quinones of anthracyclic antibiotics.

CDF and MSA have synergistic effects with epidermal growth factor (EGF) or fibroblast growth factor (FGF) in stimulating DNA synthesis of the cells. The mode of combined action of CDF or MSA with EGF or FGF in chondrocytes was studied by sequential treatments with these agents.

Purified murine epidermal growth factor (EGF) binds to mouse and human cells. Two mouse transformed cell lines of different origins, PG19 and B82, were found to lack EGF receptors (EGFR). The defect in each of these two cell lines seems to be identical because they fail to complement each other.

2024年3月28日 · 类器官培养中最经典的细胞因子培养方案为 WNER （分别代表：Wnt-3a、Noggin、EGF和R-Spondins），这4种因子的增减组合可以适用于几乎所有的类器官培养实验，表皮生长因子EGF常与其受体结合，诱导增生性变化，另有研究表明，在 ENR （EGF、Noggin和R-Spondins））培养基 ...

2001年1月1日 · Epidermal growth factor (EGF) stimulated DNA synthesis, RNA synthesis and cell division of rabbit costal chondrocytes in culture, but did not stimulate nor inhibit proteoglycan synthesis. Multiplication-stimulating activity (MSA) and cartilage-derived factor (CDF) with somatomedin-like activity had …

表皮生长因子 家族成员包括表皮生长因子（EGF）、 转化生长因子α （TGFα）、 双调蛋白 （AR）、β-乙酰球蛋白 betacellulin （BTC）、 肝素结合表皮生长因子样生长因子 （HB-EGF）、表面活性物质（EPR）、表观蛋白（EPG）、神经调节蛋白（NRGs）、神经调节蛋白-2s ...

2021年5月28日 · The MD simulations of the EGF mutants show a long-range effect on the receptor dimer interface. For the first time in this study, a single mutation in EGF is shown to be enough to alter the activation of the pathway at the cellular level.