2011年12月1日 · Here we demonstrate, in human cancer cells, that epidermal growth factor receptor (EGFR) activation induces translocation of PKM2, but not PKM1, into the nucleus, where K433 of PKM2 binds to...

Here, we demonstrated that EGF promoted O-GlcNAc transferase (OGT) binding to PKM2 by stimulating OGT Y976 phosphorylation. As a consequence, we found PKM2 O-GlcNAcylation and detetramerization were upregulated, leading to a significant decrease in PKM2 activity.

2011年12月1日 · PKM2-dependent β-catenin transactivation is instrumental in EGFR-promoted tumour cell proliferation and brain tumour development. In addition, positive correlations have been identified between c-Src activity, β-catenin Y333 phosphorylation and PKM2 nuclear accumulation in human glioblastoma specimens.

2012年11月25日 · Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that...

2022年2月9日 · Here, we demonstrated that EGF promoted O -GlcNAc transferase (OGT) binding to PKM2 by stimulating OGT Y976 phosphorylation. As a consequence, we found PKM2 O -GlcNAcylation and detetramerization were upregulated, …

2024年11月26日 · 细胞核PKM2,并测定饱和底物情况下PKM2的活性,研究发现组蛋白H1和赖氨酸 能明显降低PKM2催化PEP生成丙酮酸的速率,组蛋白H1或赖氨酸能接受PEP所

2016年4月26日 · Upon growth factor stimulation or in some EGFR mutant cancer cells, PKM2 translocates into the nucleus to induce glycolysis and cell growth. Here, we report that nuclear PKM2 binds directly to poly-ADP ribose, and this PAR-binding capability is …

2016年4月26日 · In this report, we demonstrated that PARP1-dependent poly-ADP-ribose (PAR) is required for nuclear retention and nuclear function of PKM2. PKM2 translocates into nucleus and binds to PAR upon EGF stimulation. PARP inhibition, or the PKM2-C/A mutant, which abolishes the PKM2/PAR interaction, suppresses the nuclear function of PKM2.

2011年12月1日 · PKM2 依赖性 β-连环蛋白反式激活有助于 EGFR 促进的肿瘤细胞增殖和脑肿瘤发展。 此外，已确定 c-Src 活性之间存在正相关关系，β-连环蛋白 Y333 磷酸化和 PKM2 在人胶质母细胞瘤标本中的核积累。

2015年10月26日 · PKM2 silencing resulted in markedly reduced mutant EGFR expression in TKI-sensitive or -resistant human lung cancer cells, and in inhibition of tumor growth in their xenografts, concomitant with...