EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

2024年12月24日 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia. Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling.

2021年11月10日 · Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders.

2021年3月24日 · Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis.

2024年11月2日 · The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] Expression

The transcription factor, early growth response-1 (Egr-1) is the product of a prototypic immediate-early gene that plays an integral role in the pathogenesis of multiple cardiovascular diseases. Egr-1 has been linked with atherogenesis, myocardial ...

Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia; Egr1 is the oncostatin M-induced transcription factor that binds to the SIRE sequence of the LDL receptor promoter; Review examines emerging evidence that ERG-1 orchestrates transcriptional response to vascular injury.

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a Cancer suppressor gene. [provided by RefSeq, Dec 2014]

Egr1 or the early growth response–1 gene product is a zinc-finger transcription factor of 59,000 Daltons that, unusually, appears to activate transcription by binding to DNA as a monomer. The role of Egr1 in cancer was last reviewed in these pages in 1998 1.

1999年4月1日 · The EGR family of transcription regulatory factors, which is implicated in orchestrating the changes in gene expression that underlie neuronal plasticity, has attracted the attention of both molecular and systems neuroscientists. In this article, the advances made in both these fields of research are reviewed.