2011年2月1日 · For example, EHD2 interacts with EH-domain-binding protein 1 (EHBP1) [37], a binding partner that contains a cytoskeleton-interacting calponin homology (CH) domain, as well as five asparagine–proline–phenylalanine (NPF) …

2025年2月26日 · We show that human fibrotic MASH livers have decreased EH-domain-binding protein 1 (EHBP1), a genome-wide association study (GWAS) locus associated with low-density lipoprotein (LDL) cholesterol, and that EHBP1 loss- and gain-of-function increase and decrease MASH fibrosis in mice, respectively.

2004年3月12日 · Here we identified two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton. EHD2 contains an N-terminal P-loop and a C-terminal EH …

2025年3月6日 · 研究表明，人类纤维化的 MASH 肝脏中与低密度脂蛋白胆固醇相关的全基因组关联研究（GWAS）位点 EH-domain-结合蛋白 1（EHBP1）减少以及EHBP1 的功能缺失能够促进 MASH 纤维化水平 。

EHD1 and EHD2 interact with an actin-binding protein, EHBP1, through the NPF motif found within EHBP1 . Our model suggests that the ferlins and EHBP1 may compete for EHD binding to regulate the complex process of exit from the endocytic recycling compartment, translocation to the plasma membrane, and reorganization of the actin cytoskeleton to ...

We show that all human EHD proteins rescue the vacuolated intestinal phenotype of C. elegans rme-1 mutant, are simultaneously expressed in a panel of mammalian cell lines and tissues tested, and variably homo- and hetero-oligomerize and colocalize with each other and Rab11, a recycling endosome marker.

2004年9月17日 · Here, we report that an Eps15 homology (EH) domain-containing protein, EHD1, controls the normal perinuclear localization of GLUT4-containing membranes and is required for insulin-stimulated recycling of these membranes in cultured adipocytes.

2022年11月24日 · We propose a model where caveolins, cavins, and EHD2 assemble as a cohesive structural unit regulated by intermittent associations with pacsin2 and EHBP1. These coats can flatten and curve to...

2012年4月24日 · Another EHD interaction that could be disrupted by blocking the EH domain is that with EHBP1. EHBP1 is an actin-binding protein that is thought to link the actin cytoskeleton to sites of endocytosis by binding to the EH domain of EHD2 in mammals .

2024年2月7日 · Among those, 54 and 41 sequences represented Cobl-like and Cobl, respectively, and 26 sequences identified represented EHBP1, a multidomain EHD protein-binding protein thought to be involved in membrane trafficking functions via its Rab8- and Rab10-binding C terminus containing a bMERB domain (Wang et al., 2016; Rai et al., 2016, 2020; Li et al ...