A review on CXCR4/CXCL12 axis in oncology: No place to hide
Tumour cells utilise CXCR4 to access the CXCL12-rich bone marrow microenvironment that favours their growth and survival. High levels of CXCL12 secretion by bone marrow stromal …
《普创新》趋化因子受体CXCR4及其配体 - 知乎 - 知乎专栏
CXCR4的基础表达主要受 核呼吸因子1 (Nuclear Respiratory Factor 1 ,NRF-1)和 核转录因子Yin-Yang 1 (YY1)的调节，前者促进受体转录，而后者负调节[9,10]。CXCR4响应不同的信号分子以 …
Modeling the SDF-1/CXCR4 protein using advanced artificial …
2024年2月2日 · We first predicted 3D structures for SDF-1/CXCR4 protein of Japanese anchovy (EJ SDF-1/EJ CXCR4) using Colab Fold, obtained a reference protein 3D structure model, …
Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the …
2024年8月27日 · Here, we present the cryoelectron microscopy (cryo-EM) structure of the CXCL12-CXCR4-Gi complex at an overall resolution of 2.65 Å. CXCL12 forms a 1:1 …
Comprehensive structural investigation of a potent and selective CXCR4 …
2024年12月5日 · We identified a novel heptapeptide that fully replicates the pharmacological profile of the parent peptide on CXCR4, including its potency, selectivity, and antagonistic …
Expression and potential role of chemokine receptor CXCR4 in …
Immunofluorescent imaging and flow cytometry were performed to examine the expression of CXCR4 in the EJ and EJ-M3 cell lines. A highly specific CXCR4 antagonist, AMD3100, was …
CXCR4 in breast cancer: oncogenic role and therapeutic targeting
Recently, CXCR4 has been reported to play an important role in cell survival, proliferation, migration, as well as metastasis of several cancers including breast cancer. This review is …
CXCR4基因沉默对膀胱癌细胞侵袭力及腔内种植影响的实验研究
结论:以CXCR4为靶向的siRNA能够有效下调基因;可以明显的抑制细胞EJ-M_3CXCR4 mRNA的转录水平及CXCR4蛋白的表达;能降低SDF-1诱导的膀胱癌细胞系体外侵袭能力及增殖活性;同时 …
Development and therapeutic perspectives of CXCR4 antagonists …
2024年9月5日 · Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is involved …
A review on CXCR4/CXCL12 axis in oncology: No place to hide
In this review, we summarise the role of CXCR4 and CXCL12 in tumour growth, metastasis, angiogenesis, and cancer cell-microenvironment interaction. Furthermore, we discuss the …