Objective: Australian EDs are required to conform to the National Emergency Access Target (NEAT): patients must depart within 4 h of arrival. The study's aim was to determine if a nursing role called the 'Emergency Journey Coordinator' (EJC) improved NEAT through resolving delays in patient processing.

2014年4月7日 · Australian EDs are required to conform to the National Emergency Access Target (NEAT): patients must depart within 4 h of arrival. The study's aim was to determine if a nursing role called the ‘Emergency Journey Coordinator’ (EJC) improved NEAT through resolving delays in patient processing.

An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization of the spliced mRNA, and m …

Mutant brains contained fewer neurons and progenitors, but no apoptosis, all phenotypes explained by developmental delay. This finding, which contrasts with severe neural phenotypes evident in other EJC mutants, indicates Casc3 is largely dispensable for brain development.

The exon junction complex (EJC) consists of a set of nuclear proteins that bind to pre-mRNA transcripts during splicing and that are required for the cytoplasmic localization of oskar mRNA in Drosophila oocytes [98].

2024年5月27日 · EJC主要通过激活带有早终止密码子（PTC）且位于最后一个内含子之前转录物的无义介导降解（NMD）来参与mRNA质控。 此外，EJC还影响可变剪接、转录物核输出、翻译效率和抑制mRNA的m6A甲基化。

The presence of EJC (left) slows down RNA Pol II elongation (shown by the inhibitory arrow) to introduce a delay in transcription of downstream strong splice site.

In the case of 3′UTR EJC-dependent NMD, the EJC delays termination. Delay is in part due to the binding of UPF1 and its phosphatidylinositol 3-kinase-related kinase SMG1 to the terminating ribosome along with the eRF1–eRF3 complex, forming the SURF complex (SMG1–UPF1–eRF1–eRF3; Kashima et al. 2006).

The exon junction complex (EJC) plays a crucial role in regulating gene expression at the levels of alternative splicing, translation, mRNA localization, and nonsense-mediated decay (NMD). The EJC is comprised of three core proteins: RNA-binding ...

2009年4月28日 · Ma等表明EJC使mTOR信号传导途径下游的翻译活化，而Isken等证明，参与无意义突变介导的mRNA降解（NMD）的EJC的结合分子可抑制翻译。 0 v. j& T' F, e6 Y " A ( T; Z c+ W0 ], h: p ?1 x. Q! e, ] & X% D5 I# V- q- p% | 真核生物信使RNA (mRNA)不仅含有作为蛋白质合成模板的整个开放读框，而且含有调节mRNA的细胞核输出、亚细胞定位、翻译和稳定性的信息。 大多数这类信息由包括mRNA—蛋白质 (mRNP)在内的与mRNA结合的蛋白质携带。 然而，这些 …