2024年12月24日 · ELOVL4 (ELOVL Fatty Acid Elongase 4) is a Protein Coding gene. Diseases associated with ELOVL4 include Spinocerebellar Ataxia 34 and Stargardt Disease 3. Among …

ELOVL4 is a member of a large family of fatty acid elongases (ELO) that catalyzes the rate-limiting step in the elongation of long chain fatty acids (LC-FA) into very long-chain saturated …

2019年3月1日 · In this review, we critically compare and contrast the various animal model and case studies involving ELOVL4 deficiency via either mutation or deletion, and the resulting …

2023年11月20日 · ELOVL4 regulates the synthesis of very long-chain (≥ C28) polyunsaturated fatty acids, including n-3 VLC-PUFAs, and has been implicated in neuroprotective signaling for …

Using cell-based and cell-free microsome assays, we found that the truncated protein lacked innate condensation activity. Coexpression of different forms of wild-type and mutant ELOVL4 …

ELOngation of Very Long chain fatty acids-4 (ELOVL4) is an elongase responsible for the biosynthesis of very long chain (VLC, ≥C28) saturated (VLC-SFA) and polyunsaturated (VLC …

2025年3月1日 · ELOVL4 is the most frequently mutated gene in the elongase complex, associated with both AD and AR disorders (Table 3). ELOVL4 is widely expressed in CNS …

该基因编码一种膜结合蛋白，它是 ELO 家族的一员，参与脂肪酸生物合成的蛋白质。 与视网膜感光细胞中编码蛋白的表达一致，该基因的突变和小缺失与 Stargardt 样黄斑营养不良 (STGD3) …

2019年9月20日 · ELOVL4 and its VLC-SFA and VLC-PUFA products are emerging as important regulators of synaptic signaling and neuronal survival in the central nervous system (CNS). …

Numerous investigations have revealed that ELOVL4 is essential for the synthesis of fatty acids, and it is generally accepted that this enzyme’s purpose is to extend C20 fatty acids to longer …