Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration.

2024年12月25日 · EPAS1 (Endothelial PAS Domain Protein 1) is a Protein Coding gene. Diseases associated with EPAS1 include Erythrocytosis, Familial, 4 and Multiple Paragangliomas Associated With Polycythemia. Among its related pathways are Selective autophagy and Signaling by PTK6.

内皮PAS结构域包含蛋白-1 （英語： Endothelial PAS domain-containing protein 1，缩写 EPAS1，也被称为 缺氧诱导因子-2α亚基，英語： Hypoxia-inducible factor-2alpha，缩写 HIF-2α）是一种由人类 基因 EPAS1 所编码的 蛋白质 [6][7][8][9]。 EPAS1所表达的蛋白是一个 转录因子 的组成部分，该转录因子介导一些受 氧气 调控基因的表达，特别是低氧（缺氧）环境下。 该蛋白包含一个 碱性螺旋-环-螺旋 蛋白二聚化结构域，此结构域也常见于其它氧应激相关信号通 …

The EPAS1 gene, often known as HIF2A, provides instructions for making a protein called hypoxia-inducible factor 2-alpha (HIF-2α). This protein is one part (subunit) of a larger protein complex called HIF, which plays a critical role in the body's ability to …

在 血液中的含氧量降低时，这一叫做epas1的基因被激活，触发生成更多的血红蛋白。 因为在低海拔地区，这一基因的某些变异可帮助运动员迅速增加血红蛋白， 由此提高他们的血液携氧能力，增加耐力，该基因被称作为超级运动（superathlete）基因。

2025年1月4日 · Knockdown of endothelial PAS domain protein 1 (EPAS1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed Protein interactions

EPAS1 promotes peritoneal carcinomatosis of non-small-cell lung cancer by enhancing mesothelial-mesenchymal transition. Hypoxia-inducible factor 2 alpha impairs human cytotrophoblast syncytialization: New insights into placental dysfunction and …

该基因编码的转录因子参与诱导受氧调节的基因，随着氧水平下降而被诱导。 编码的蛋白质包含一个碱性-螺旋-环-螺旋结构域蛋白质二聚化结构域，以及在信号转导通路中对氧水平作出反应的蛋白质中发现的结构域。 该基因的突变与 4 型家族性红细胞增多症有关。 [RefSeq 提供，2009 年 11 月] This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall.

内皮pas1蛋白（epas1/hif-2）是细胞应对缺氧时关键的转录因子,在生物体生理及病理过程中有重要作用。文中对epas1的结构、分布、表达调控及在病理过程中的作用、高原低氧适应性方面进行了综述,为今后进一步研究epas1提供了参考和借鉴。

EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo. Tian et al. (1997) suggested that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia.