2023年9月15日 · ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating transcription factor 6, and …

2024年2月20日 · In recent decades, abundant evidence has highlighted the significance of endoplasmic reticulum stress (ERS) in advancing central nervous system (CNS) disorders, …

2021年8月1日 · Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca 2+ homeostasis. The stress response of ER results from the …

2024年11月1日 · We provide a comprehensive synthesis of evidence from animal models, examining neuronal and non-neuronal mechanisms and discuss the damaging ER stress …

2011年1月1日 · ER stress has been well documented in various brain pathologies, including cerebral stroke, when stress leads to mitochondrial dysfunction, depletion of ER luminal Ca …

2017年7月21日 · In this Review, we discuss the latest advances in defining the functional contribution of ER stress to brain diseases, including novel evidence that relates the UPR to …

Disturbances in the physiological functions of the ER result in the activation of a complex set of signaling pathways from the ER to the cytosol and nucleus, and these are collectively known …

2017年5月25日 · Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and …

Here, we report that dysfunction of an ER-resident Ca2+ channel, inositol 1,4,5-trisphosphate receptor (IP3R), promotes cell death during ER stress. Heterozygous knockout of brain …

2024年3月1日 · ER stress activates unfolded protein response (UPR) sensors, initiating distinct downstream responses aimed at improving ER folding, inhibiting translation, and reinforcing …