ERK家族成员 - 百度百科
ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。 许多其他信号通路明显活化时，可活化蛋 …
快速了解ERK/MAPK信号通路？ - 知乎专栏
erk是一种丝氨酸/苏氨酸蛋白激酶，是一种传递有丝分裂原信号的信号转导蛋白。erk通常位于细胞质中；在被激活后，erk进入细胞核，调节转录因子活性和基因表达。erk家族已被证实包 …
Extracellular signal-regulated kinases - Wikipedia
ERKs are known to activate many transcription factors, such as ELK1, [1] and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf, …
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK …
信号转导的风暴中心：ERK1/2 - 知乎 - 知乎专栏
ERK1/2是 RAF-MEK-ERK信号通路 的关键组成部分，在 Thr202 、 Tyr204 位点被磷酸化从而激活，进而激活多种与细胞增殖、分化、迁移和血管生成相关的底物（超过160种）。因此ERK1/2 …
ERK1/2 MAP kinases: structure, function, and regulation
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety …
ERK 通路 | Cell Signaling Technology
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
ERK1/2 MAP kinases: Structure, function, and regulation
2012年8月1日 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this …
ERK/MAPK signalling pathway and tumorigenesis - PMC
The extracellular signal-regulated kinases ERK1 and ERK2 are evolutionarily conserved, ubiquitous serine-threonine kinases that regulate cellular signalling under both normal and …
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
In this review we compiled data on ERK1 vs. ERK2 gene structures, protein sequences, expression levels, structural and molecular mechanisms of activation and substrate recognition.