2024年10月18日 · Here we show that ESCC can be categorized into differentiated, metabolic, immunogenic and stemness subtypes based on bulk and single-cell RNA-seq, each exhibiting specific molecular and...

Esophageal squamous carcinoma (ESCC) is one of the most common cancers in developing countries. However, currently there are no specific biomarkers for ESCC. This study evaluated the expression of proliferating cell nuclear antigen (PCNA), tumor ...

2017年8月17日 · We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor (EGFR), Cyclin D1, vascular endothelial growth factor (VEGF), Survivin, Podoplanin, Fascin, phosphorylated mammalian target of rapamycin (p-mTOR), and pyruvate kinase M2 (PKM2)] indicating unfavorable prognosis and 3 ...

Abstract Background. Esophageal small cell carcinoma (ESCC) is an aggressive disease with poor prognosis. This study sought to describe immunohistochemical (IHC) and clinicopathological features of patients with ESCC, and to clarify how the utilization of different marker combination affects prognostic outcome.

2017年8月17日 · Strong evidence supports that these 11 emerging IHC markers or their combinations may be useful in predicting prognosis and aiding personalized therapy decision-making for ESCC patients.

2021年9月6日 · Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we...

1 天前 · Immunohistochemistry (IHC) analysis was conducted on tissue microarrays (TMAs) containing samples from 89 to 91 ESCC patients, respectively. Ultimately, based on the cut-off values derived from two TMAs using time-dependent receiver operating characteristic (ROC) curve analysis, 77 and 103 patients were stratified into high-expression and low ...

2024年12月19日 · Our findings identify EZH2 as a potential therapeutic target and point to avenues for targeted therapy applied to patients with ESCC characterized by CD8 + T cell-desert tumors.

食管鳞状上皮癌前病变（Esophageal squamous precancerous lesions, ESPL）是ESCC的前体病变，表现出从正常上皮（NE）到低级别（LGIN）和高级别（HGIN） 上皮内瘤变 的进展，最终发展为浸润性癌。 一份长达13.5年的随访数据表明，较高级别的上皮内瘤变与ESCC发生的风险明显相关。 目前， 尚不明确哪些阶段的ESPL最终会发展成ESCC，因此需要找到与ESPL进展为ESCC相关的风险指标，以进行精准预防。

2024年5月9日 · Methods: We investigated the expression of CD276 in ESCC tissues from patients by using immunohistochemistry (IHC) assays. In vivo, we established a 4-nitroquinoline 1-oxide (4NQO)-induced CD276 knockout (CD276 wKO ) and K14cre; CD276 conditional knockout (CD276 cKO ) mouse model of ESCC to study the functional role of CD276 in ESCC.