2024年12月25日 · ESM1 (Endothelial Cell Specific Molecule 1) is a Protein Coding gene. Diseases associated with ESM1 include Macrotrabecular Hepatoblastoma and Gastric Cancer. Among its related pathways is Gastric cancer network 1. Gene Ontology (GO) annotations related to this gene include integrin binding and hepatocyte growth factor receptor binding.

Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene. [5] [6] This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues.

2025年2月8日 · Esm-1 mediates transcriptional polarization associated with diabetic kidney disease. ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment.

ESM1, also called Endocan, is a 50 kDa cysteine-rich secreted proteoglycan, containing a 20 kDa core protein and a single dermatan sulfate chain. In normal tissues, ESM1 is secreted by vascular endothelial cells, epithelial cells lining renal distal tubules, bronchi, and lung submucosal glands.

2014年7月23日 · We generated and analyzed Esm1 knockout (Esm1 KO) mice to study its role in angiogenesis and inflammation. Esm1 expression is induced by the vascular endothelial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina. Esm1 KO mice showed delayed vascular outgrowth and reduced filopodia extension, which are both VEGF-A–dependent ...

Endothelial cell specific molecule-1 (ESM1), also known as endocan, is a marker of endothelial cell dysfunction. Although ESM1 is primarily expressed in normal endothelial cells, dysregulated ESM1 expression has been observed in human tumors and animal tumor models, and implicated in tumor growth, metastasis and angiogenesis.

该基因编码一种分泌蛋白，主要在人肺和肾组织的内皮细胞中表达。 该基因的表达受细胞因子调节，表明它可能在内皮依赖性病理障碍中发挥作用。 转录物包含多个聚腺苷酸化和 mRNA 不稳定信号。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2008 年 10 月] This gene encodes a secreted protein which is mainly expressed in the endothelial cells in …

ESM-1, also called Endocan, is a 50 kDa cysteine-rich secreted proteoglycan, containing a 20 kDa core protein and a single dermatan sulfate chain. In normal tissues, ESM1 is secreted by vascular endothelial cells, epithelial cells lining renal …

内切酶（ESM1）主要表达于人肺和肾组织内皮细胞中，据报道其参与多种癌症的增殖、迁移、侵袭等过程，并通过调控AKT/NF-kappaB/Cyclin D1、Wnt/β-catenin等信号通路来参与肿瘤的发生发展过程。 因此，通过初步探讨ESM1基因在OC疾病中的生物学功能来进一步阐明其在OC疾病发生发展中的作用。 为此，本研究基于Gene Expression Omnibus（GEO）数据库的两个转录组数据集，采用 加权基因共表达网络分析 （WGCNA）方法验证OC患者与正常女性之间的差异表达基 …

Endothelial-specific molecule 1 (ESM1), also known as endocan, is a proteoglycan abundantly expressed in the vascular endothelium 17. ESM1 has been implicated in the progression or metastasis of many malignancies, including pathogenic processes such as cell migration, invasion, and carcinoma angiogenesis 18.