2020年8月6日 · The endothelial-to-mesenchymal transition (EndoMT) is involved in the complex pathogenesis of renal fibrosis. The soluble proteoglycan endothelial cell-specific molecule 1 …

2025年1月7日 · Subsequent RNA-sequencing (RNA-seq) revealed ESM1 as the most significantly upregulated gene in tumor-derived CD31 + cells compared to the non-neoplastic counterparts …

2024年7月10日 · CD31 + CD45 − ECs showed consistent expression of classical endothelial markers, such as CD31, VWF and CLDN5, while not expressing PVC markers …

Here, we present a semisynthetic low-molecular sulfated chitosan oligosaccharide (SCOS) that efficiently induces therapeutic arteriogenesis with a spontaneous generation of collateral …

The SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway. This activation promotes the migration and …

2014年7月23日 · We generated and analyzed Esm1 knockout (Esm1 KO) mice to study its role in angiogenesis and inflammation. Esm1 expression is induced by the vascular endothelial …

2024年10月9日 · Results: SOX4 is highly expressed in IH tissues and promotes the proliferation, migration, and angiogenesis of CD31+ HemECs. In addition, SOX4 binds to the endothelial …

该研究发现，ESM1在胃癌组织中的表达显著上调，并与血小板内皮细胞黏附分子-1（CD31）水平呈正相关。 进一步的临床验证、体外和体内实验证实，ESM1促进胃癌血管生成，最终促进胃 …

We found that ESM1 overexpression resulted in the increased expression of N-cadherin, MMP-9, vimentin and α-smooth muscle actin (α-SMA) and decreased the expression of vascular …

2023年12月30日 · Herein, we demonstrated that ESM1 expression was significantly upregulated in gastric cancer tissues and positively correlated with platelet endothelial cell adhesion …