2020年8月6日 · The endothelial-to-mesenchymal transition (EndoMT) is involved in the complex pathogenesis of renal fibrosis. The soluble proteoglycan endothelial cell-specific molecule 1 (ESM1) is significantly upregulated in many tumor cells and cirrhosis-related disease. The role of ESM1 in renal fibrosis is unk …

2025年1月7日 · Subsequent RNA-sequencing (RNA-seq) revealed ESM1 as the most significantly upregulated gene in tumor-derived CD31 + cells compared to the non-neoplastic counterparts (Fig. 1c). In the TCGA...

2024年7月10日 · CD31 + CD45 − ECs showed consistent expression of classical endothelial markers, such as CD31, VWF and CLDN5, while not expressing PVC markers (Supplementary Fig. 1a–o), thereby confirming the...

Here, we present a semisynthetic low-molecular sulfated chitosan oligosaccharide (SCOS) that efficiently induces therapeutic arteriogenesis with a spontaneous generation of collateral circulation and blood reperfusion in rodent models of hind limb ischemia and myocardial infarction.

The SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway. This activation promotes the migration and angiogenic behaviors of CD31+ HemECs, facilitating the occurrence and progression of IH.

2014年7月23日 · We generated and analyzed Esm1 knockout (Esm1 KO) mice to study its role in angiogenesis and inflammation. Esm1 expression is induced by the vascular endothelial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina. Esm1 KO mice showed delayed vascular outgrowth and reduced filopodia extension, which are both VEGF-A–dependent ...

2024年10月9日 · Results: SOX4 is highly expressed in IH tissues and promotes the proliferation, migration, and angiogenesis of CD31+ HemECs. In addition, SOX4 binds to the endothelial cell-specific molecule 1 (ESM1) promoter to promote the progression of …

该研究发现，ESM1在胃癌组织中的表达显著上调，并与血小板内皮细胞黏附分子-1（CD31）水平呈正相关。 进一步的临床验证、体外和体内实验证实，ESM1促进胃癌血管生成，最终促进胃癌腹膜转移。 机制上，ESM1通过与血管内皮细胞膜上的c-Met结合来促进肿瘤血管生成。 此外，研究结果证实，ESM1通过激活MAPK/ERK通路上调VEGFA、HIF1α和MMP9的表达并诱导血管生成。 本研究揭示了ESM1在胃癌血管生成和腹膜转移中的作用，为胃癌的诊断和治疗提供了新的思 …

We found that ESM1 overexpression resulted in the increased expression of N-cadherin, MMP-9, vimentin and α-smooth muscle actin (α-SMA) and decreased the expression of vascular endothelial cadherin (VE-cadherin) and CD31 in MES 13 cells, compared with control cells . These observations indicate that ESM1 may play an important role in the ...

2023年12月30日 · Herein, we demonstrated that ESM1 expression was significantly upregulated in gastric cancer tissues and positively correlated with platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, in in vitro and in vivo experiments, confirmed that ESM1 promoted gastric cancer angiogenesis, eventually promoting ...