To T or not to T: reassessing the common lymphoid progenitor
2003年1月6日 · Furthermore, T cell production from ETPs is sustained for longer periods of time when compared with CLPs, further suggesting that they represent a more primitive progenitor …
Notch Signaling in the Bone Marrow Lymphopoietic Niche - PMC
The critical temporal question is whether Notch signaling is activated and required for development of the LMPP, CLP or the ETP. Early insight into the role of Notch in BM T lineage …
Mapping T-ALL to T Cell Differentiation Trajectory Identifies an ETP ...
2024年11月5日 · ETP-ALL and near-ETP-ALL showed similar distribution patterns of hematopoietic stem cell (HSC), lymphoid-primed multipotent progenitors (LMPP), common …
基础免疫学：T细胞发育 | 免疫学专题_cTECs - 搜狐
2020年11月20日 · 在胸腺中，t细胞的发育以高度结构化的顺序从etp发育而来，其特征是一组特定的表面分子的表达。最早阶段的特征是在成熟的胸腺细胞表面上没有cd3 （cd3包含四条 …
common lymphoid progenitor (CLP) in bone marrow. The cell commitment of T cells and ILCs appears in the thymus or bone marrow, respec-tively. Downstream of CLPs, the generation of …
CLP. Instead, the most immature T cell progeni-tors in the CD44+CD25–Linneg pool of cells seg-regated with a Linnegc-kithiIL-7Rαneg/lo phenotype, termed the early T lineage progenitor …
急性早期前体T淋巴细胞白血病的研究新进展 - 国际输血及血液学 …
急性早期前体t淋巴细胞白血病(etp-all)是2016年世界卫生组织(who)淋巴造血组织肿瘤分类中的独立亚型之一，其具有独特的生物学特征，临床上表现为高度侵袭性，患者长期预后较差。
Common-Lymphoid-Progenitor-Independent Pathways of Innate …
2016年4月19日 · All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than …
2021-03-16 T细胞发育 - 简书
2021年3月16日 · T细胞也是由造血干细胞发育而来，在骨髓内的前期发育过程与B细胞具有共同祖先——普通淋巴祖细胞common lympoid progenitor cell (CLP)。 部分CLP离开骨髓，随血液 …
TCF-1 upregulation identifies early innate lymphoid progenitors …
Using novel reporter mice, we identified a new subset of early ILC progenitors (EILP) that expressed high amounts of TCF-1. EILP lacked efficient T and B lymphocyte potential, but …