2019年2月12日 · From our study, we demonstrate an important role for antigen non-related bystander CD4 + T cells in EAE pathogenesis, which are activated by IL-1β together with IL …

2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + …

实验性自身免疫性脑脊髓炎（experimental autoimmune encephalomyelitis，EAE）是一种以特异性致敏的CD4+T细胞介导为主的，以中枢神经系统内小血管周围出现单个核细胞浸润及髓鞘脱 …

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS) often used as a model for the early inflammatory stages of multiple …

2017年7月5日 · Here we describe protocols for passive transfer model of EAE using freshly isolated (MOG)-specific CD4 + T cells or periodically restimulated MOG-specific CD4 + T cell …

2014年10月7日 · Here we show that nicotinamide adenine dinucleotide (NAD +) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing …

To fully understand how ALKBH5 regulates CD4 + T cell responses in vivo, we used the EAE model in which CD4 + T cells are critical to initiate a localized inflammatory process . We …

2019年8月22日 · 美国斯坦福大学医学院Mark M. Davis课题组发现了实验性自身免疫性脑脊髓炎（EAE）中T细胞反应的对抗机制，相关论文发表在2019年8月22日出版的《自然 ...

本研究应用c57bl/6小鼠制备eae模型 ，通过观察不同发病时期小鼠外周免疫器官(脾脏)中cd4 ＋ t细胞表面cd1d表达水平的变化，探讨多发性硬化病情进展过程中，cd1d分子的影响机制。

2014年1月1日 · In active EAE, the induction of disease relies upon initiation of a peripheral immune response following immunization with myelin antigens in adjuvant. Subsequently, …