2019年2月12日 · From our study, we demonstrate an important role for antigen non-related bystander CD4 + T cells in EAE pathogenesis, which are activated by IL-1β together with IL-23. These cells are the major...

2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + and γδ + T cells in the blood...

实验性自身免疫性脑脊髓炎（experimental autoimmune encephalomyelitis，EAE）是一种以特异性致敏的CD4+T细胞介导为主的，以中枢神经系统内小血管周围出现单个核细胞浸润及髓鞘脱失为特征的自身免疫性疾病，其病…

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS) often used as a model for the early inflammatory stages of multiple sclerosis and also as a model of organ-specific autoimmune disease.This protocol describes the induction of passive EAE in …

2017年7月5日 · Here we describe protocols for passive transfer model of EAE using freshly isolated (MOG)-specific CD4 + T cells or periodically restimulated MOG-specific CD4 + T cell lines, which are suitable for tracking pathogenic CD4 + T cells in vivo, particularly in the CNS ( Ogura et al., 2008 ; Arima et al., 2012 and 2015b).

2014年10月7日 · Here we show that nicotinamide adenine dinucleotide (NAD +) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ +...

To fully understand how ALKBH5 regulates CD4 + T cell responses in vivo, we used the EAE model in which CD4 + T cells are critical to initiate a localized inflammatory process . We documented that ALKBH5 deficiency in CD4 + T cells renders mice resistant to EAE.

2019年8月22日 · 美国斯坦福大学医学院Mark M. Davis课题组发现了实验性自身免疫性脑脊髓炎（EAE）中T细胞反应的对抗机制，相关论文发表在2019年8月22日出版的《自然 ...

本研究应用c57bl/6小鼠制备eae模型 ，通过观察不同发病时期小鼠外周免疫器官(脾脏)中cd4 ＋ t细胞表面cd1d表达水平的变化，探讨多发性硬化病情进展过程中，cd1d分子的影响机制。

2014年1月1日 · In active EAE, the induction of disease relies upon initiation of a peripheral immune response following immunization with myelin antigens in adjuvant. Subsequently, activated myelin-reactive CD4+ T cells migrate into the CNS and orchestrate immune-mediated damage to the myelin sheath surrounding neurons.