Opposing T cell responses in experimental autoimmune ... - Nature
2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + …
髓鞘抗原特异性CD8 + T细胞在MS/EAE脑组织免疫豁免中作用的研 …
在eae中，mog诱导cd4或cd8缺陷的eae小鼠cns的病灶是由cd8 + t细胞造成的；同样与野生型动物相比，mog1-125诱导在cd8缺陷dba/1的eae小鼠中可发现脱髓鞘和cns炎症的减少。
Myelin-specific CD8 + T cells exacerbate brain inflammation in …
2019年10月1日 · Here, we investigated whether naive MBP-specific CD8 + T cells recruited to the CNS during CD4 + T cell–initiated EAE engaged in determinant spreading and influenced …
CD8+ T cells specific for cryptic apoptosis-associated epitopes ...
2021年10月29日 · Our data indicate that AE-specific CD8 + T cells accumulate in the CNS of mice with EAE where they actively contribute to disease exacerbation. We have previously …
Nature：CD8 T细胞可对自身免疫性疾病提供保护 - 知乎
Regulators to the rescue 一种被称为CD8 T细胞的免疫细胞通常杀死致病因子，现已发现它能抑制自身反应性免疫细胞，从而对小鼠自身免疫性疾病提供保护。 作者：HYE-JUNG KIM & …
Myelin-reactive CD8+ T cells influence conventional dendritic cell ...
2025年2月28日 · We previously demonstrated that adoptively transferred myelin-reactive CD8 + T cells (PLP-CD8) prevent EAE induction and suppress ongoing disease through the …
Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE …
2018年6月27日 · Our data suggest a novel therapeutic nanoparticle to directly modulate autoreactive T cells by surface presentation of multiple ligands and paracrine release of …
Chronological changes of CD4(+) and CD8(+) T cell subsets in the ...
Polymerase chain reaction analysis suggested that both CD4 (+) and CD8 (+) T cells produced IFN-gamma and TNF-alpha, while CD4 (+) T cells also produced interleukin-17 (IL-17), an …
Pathogenic MOG-reactive CD8+ T cells require MOG-reactive …
2009年8月8日 · Overall, our findings support a moderately pathogenic role for MOG37-46 CD8+ T cells and show a significant disease enhancement and sustained inflammation in the presence …
EAE发病过程中炎症细胞的动态变化检测 - 百度学术
结果:MOG35-55诱导的EAE模型组动物出现典型的EAE临床行为学及病理学表现,进行CD8/Glut-1/DAPI和CD4/Glut-1/DAPI染色,检测到CD8细胞和CD4细胞发病高峰期在脊髓中有显著地浸 …